Antiparathyroid antibodies which specifically bind to cell surfa

Details Antiparathyroid antibodies which specifically bind to cell surfa Antiparathyroid antibodies which specifically bind to cell surfa

1994-09-26

1995-12-19

Hutzell, Paula K.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

53038822, 5303891, 43524027, 4351722, 435 7021, C07K 1628, C12N 520

Patent

active

054769213

ABSTRACT:
Antibody preparations are useful in the prognosis of parathyroid and renal disorders. The antibody preparation includes antibodies which bind specifically to a surface antigen, Ca.sup.2+ sensing structure, present in humans on the parathyroid, on the proximal tubuli of the kidney, on the cytotrophoblastic cells of the placenta, on renal carcinoma cells and on parathyroid cancer cells.

REFERENCES:
patent: 4864020 (1989-09-01), Cance et al.
Juhlin et al. Biochemical and Biophysical Research Comm. 143:570-574, 1987.
Juhlin et al. PNAS USA 84: 2990-2994, May 1987.
Brodsky et al. J. Immunology 128: 129-135, 1982.
Biosis Abstract No. 79(9): 77366, Wells et al., Am. J. Reprod. Immunol. 6(4): 167-174 1984.
Biosis Abstract No. 92:78322 Beniers et al. Int. J. Cancer 48(5): 709-716, 1991.
Cance et al. Proc. Natl Acad Sci USA vol. 83, pp. 6112-6116, Aug. 1986 "Human parahyroid enatigen: Characterization and localization with monoclonal antibodies".

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