Antiparasitic terpene alkaloids

Details Antiparasitic terpene alkaloids Antiparasitic terpene alkaloids

2004-02-12

2009-02-24

Habte, Kahsay T (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S063000, C504S223000

Reexamination Certificate

active

07494992

ABSTRACT:
The present invention relates to novel terpene alkaloids and their use as antiparasitic agents. The present invention also relates to an antiparasitic agent which comprises a terpene alkaloid compound of this invention as an effective ingredient in an antiparasitic formulation.More particularly, the present invention relates to derivatives of the terpene alkaloid (1S,2R,4aS,5R,8R,8aR)-2-(acetyloxy)-8a-hydroxy-3,8-dimethyl-5-(1-methylethenyl)-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl (2S,3aR,9bR)-6-chloro-9b-hydroxy-5-methyl-1,2,3,3a,5,9b-hexahydropyrrolo[2,3-c][2,1]benzoxazine-2-carboxylate. Pharmaceutical compositions comprising the same are also disclosed.

REFERENCES:
patent: 2240100 (1990-01-01), None
patent: WO 95/19363 (1995-01-01), None
The Merck Manual of Medical Information—Home Edition, Section 17. Infections, Chapter 184 on the web site http:llwww.merck.comlmrkshared/mmanual—homelsec171184.jsp, downloaded on Nov. 26, 2003.
Stephen M. Berg et al “Journal of Pharmaceutical Sciences”, vol. 66, No. 1, Jan. 1977.

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