Antiparasitic formulation

Details Antiparasitic formulation Antiparasitic formulation

2002-03-19

2004-10-05

Levy, Neil S. (Department: 1616)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Biocides; animal or insect repellents or attractants

C424S406000, C424S522000, C424S736000, C424S742000, C424S747000, C424S748000, C424S770000, C514S316000, C514S919000

Reexamination Certificate

active

06800294

ABSTRACT:

The present invention is concerned with an antiparasitic formulation and, in particular, with an antiparasitic formulation which can be used to control ectoparasitic infestation and any contagious diseases resulting therefrom.
Ectoparasitic infections of animals such as sheep are widespread. Such parasites include, for example, ticks, mites, lice, keds, head fly and blow fly, amongst others. Ticks contribute to a condition known as tickborne fever which is an infectious disease affecting almost all sheep which graze tick-infected pastures. It is caused by the microorganism
Cytoecetes phogocytophilia,
a rickettsia transmitted via the bite of sheep ticks. Ticks also contribute to tick pyaemia, or “cripples”, which is believed to kill or disable in excess of a quarter of a million lambs each year in the UK. Mites on the other hand cause intense irritation to sheep, which react by rubbing against fence posts, or the like. If no fixed objects are available, they rub against each other spreading the disease further- Mites also cause foot scab, a mange infestation of sheep. Blowfly strike, however, is a particularly nasty condition causing untold misery and death to sheep flocks. It is caused by blowfly which feed on decomposing matter containing liquid protein upon which: the blowfly feeds and amongst which it lays its eggs. Any open wound will, attract the flies. Once the larvae hatch, the sheep can be literally eaten alive by successive waves of maggots.
Many antiparasitic formulations are known, for example, as pour-on formulations or as total immersion dips for treating sheep. Plunge dipping is a technique which is generally used to control certain parasitic infestations of sheep, such as skin parasites, because it allows thorough penetration of the fleece and access to the skin by the antiparasitic formulation. The formulations used to treat ectoparasitic infestations, generally, comprise compounds which contribute to irritancy of or toxicity to the animal upon administration thereto. Examples of such compounds include, diazinon and propetamphos, for example. Other compounds, such as pyrethroids and permethrins are suitable for pour-on formulations, whilst in plunge dips it is the organophosphates which are frequently used.
These compounds are toxic not only to the animals but to the administrators alike. Furthermore, many sheep dip formulations cannot be used to treat, for example, larval infestation of wounds such as in the case of the larvae of blowfly which feed on the dead and damaged tissue associated with wounds or scouring. Treatment of blowfly larvae is normally carried out using mild insecticidal creams. Toxic substances, such as contained in many sheep dips, cannot be applied because under no circumstances can the above mentioned formulations be applied to open wounds. The formulations used previously also contribute to are released into the environment. The use of these compounds must therefore be tightly controlled and a considerable number of regulations apply to, for example, disposal of sheep dips.
Accordingly, there exists a need for formulations which when applied to an animal can effectively eradicate common ectoparasitic infestation and any resulting contagious diseases and which formulation similarly alleviates or ameliorates the disadvantages described above whilst minimising trauma and shock to the animal.
Therefore, there is provided by a first aspect of the present invention, an antiparasitic formulation comprising in an antiparasitically effective amount, Eucalyptus oil, Cajeput oil, Lemongrass oil, Clove bud oil, Peppermint oil, Piperonyl and Piperonyl Butoxide. Preferably, the formulation is further diluted with water and in such an embodiment an amount of a suitable surfactant is also included in the formulation in addition to lanolin.
In a preferred embodiment, the formulation comprises:
% By
Volume
Eucalyptus oil
4-6
Cajeput oil
0.5-2.5
Lemongrass oil
1-3
Clove bud oil
1.5-3.5
Peppermint oil
0.5-2.5
Piperonyl
1.5-3.5
Piperonyl Butoxide
0.3-0.9
Surfactant
0.05-0.15
Lanolin
0.5-1.5
Water
 80-90%
Preferably, however, the formulation comprises in approximate amounts by volume, 5.3% Eucalyptus oil, 1.3% Cajeput oil, 2.0% Lemongrass oil, 2.5% Clove bud oil, 1.3% Peppermint oil, 2.7% piperonyl, 0.6% Piperonyl Butoxide, Surfactant 0.1%, lanolin 1% and water 83.20%.
In a preferred embodiment the formulation may be further diluted to 1 part formulation per 200 parts water, for use as a sheep dip.
The formulations according to the invention are particularly advantageous because they avoid the use of hazardous compounds such as organophosphates which can be toxic both to the animal the uses and the environment. The absence of such compounds also minimises any trauma, shock or irritancy to the animal. The formulations are also safe for use by humans without risk to health and they are also considerably less damaging to the environment. The oils used are registered with the Department of Novel Foods and Flavours at the Ministry of Agriculture Fisheries and Foods. Neither the Council of Europe's Committee of Experts on Flavouring Substances nor any other European committee has recommended limits on the use of these essential oils. These oils have been evaluated by the US Flavouring Extract Manufacturers' Association (FEMA) who have classified them as GRAS (Generally Recognised As Safe) in 1965. These assessments were published in a paper Hall R. L. and Oser B. L. (1965). The formulations of the present invention therefore avoid the use of any organophosphates, permethrins, pyrethrums or derivatives thereof so they are significantly safer for the animal, the operator and the environment,
In another aspect of the invention, the formulation according to the invention may, advantageously, be used in the treatment of an animal body so as to, for example, treat ectoparasitic infestation, such as, in sheep, and also any subsequent contagious diseases resulting from the infestation.
According to a further aspect of the invention, there is also provided use of a formulation according to the invention for the manufacture of a medicament for treating an animal of ectoparasitic infestation. The formulations may be applied directly to the animal but preferably are used in a total immersion dip, such as used in a sheep dip, thus allowing the formulation to sufficiently penetrate the fleece so as to substantially eradicate the infestation.
External parasites of sheep include, amongst others,
Damalinia ovis
(biting louse),
Linognathus ovillus
(sucking louse), Lucilia spp (blowfly), Culicoides (midges),
Hydrotaea irritans
(headfly). The formulation of the invention may be used to control infestation of sheep by these parasites. Other parasites that may be effectively eradicated by the formulation of the invention include scab mite (Psoroptes Communia Ovis), tick pyremia and other tick borne fever, sarcoptic mange and keds. The formulation of the invention is, however, particularly useful in repelling the blowfly parasite and in eradicating the larvae of the blowfly which infest open wounds in sheep or areas where scouring occurs. Thus, the formulation is particularly advantageous by virtue of its use as a dip formulation and yet which is sufficiently non-toxic to the animal that it can also be used, not only to repel the blowfly but to eradicate blowfly larvae, which cannot normally be treated with sheep dip formulations.
As is known, oil of eucalyptus is obtained from various species of eucalyptus and the resulting oils do not possess a uniform analysis. It is believed, however, that the properties of the eucalyptus oil according to the invention are not dependent on a particular source of oil of eucalyptus and one may use oil derived from
Eucalyptus globulus
and/or
Eucalyptus dives.
Eucalyptus oil is rich in cineole and desirably eucalyptus oil according to the invention comprises cineole and preferably 1-8 cineole in an amount of from approximately 35 to 90% by volume.
The invention may be more clearly described by reference to the following exampl

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