Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-01-09
2008-11-18
Saeed, Kamal (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S348000
Reexamination Certificate
active
07452915
ABSTRACT:
This invention relates to the use of certain C-10 substituted derivatives of artemisinin of general formula (I) in the treatment and/or prophylaxis of diseases caused by infection with a parasite, certain novel C-10 substituted derivatives of artemisinin, processes for their preparation and pharmaceutical compositions containing such C-10 substituted derivatives. The compounds are particularly effective in the treatment of malaria, neosporosis and coccidiosis.
REFERENCES:
patent: WO 93/08195 (1993-04-01), None
Hyung Woo, Soon et al, “Direct Conversion of Pyranose Anomeric OH-F-R in the Artemisinin Family of Antimalarial Trioxanes,” Tetrahedron Letters (1993), vol. 39, pp. 1533-1536.
Yang et al., “Artemisinin Derivatives with 12-Aniline Substitution: Synthesis and Antimalarial Activity”, Bioorganic & Medicinal Chemistry Letters, vol. 5, No. 16, pp. 1791-1794 (1995).
Chan Ho-Wai
Cheung Man-Ki
Greif Gisela
Haynes Richard K.
Lam William Wai-Lun
Coppins Janet L
Heslin Rothenberg Farley & Mesiti PC
Saeed Kamal
The Hong Kong University of Science and Technology
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