Antiparasitic artemisinin derivatives (endoperoxides)

Details Antiparasitic artemisinin derivatives (endoperoxides) Antiparasitic artemisinin derivatives (endoperoxides)

2006-01-09

2008-10-21

Shiao, Rei-tsang (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S058200, C544S061000, C544S378000

Reexamination Certificate

active

07439238

ABSTRACT:
This invention relates to the use of certain C-10 substituted derivatives of artemisinin of general formula (I) in the treatment and/or prophylaxis of diseases caused by infection with a parasite, certain novel C-10 substitued derivatives of artemisinin, processes for their preparation and pharmaceutical compositions containing such C-10 substituted derivatives. The compounds are particularly effective in the treatment of malaria, neosporosis and coccidiosis.

REFERENCES:
patent: 6649647 (2003-11-01), Haynes et al.
patent: 6984640 (2006-01-01), Haynes et al.
patent: WO 93/08195 (1993-04-01), None
Woo et al, “Direct Conversion of Pyranose Anomeric OH->F->R in the Artemisinin Family of Antimalarial Trixoanes”, Tetrahedron Letters 39 (1998) pp. 1533-1536.
Yang et al., “Artemisinin Derivatives with 12-Aniline Substitution: Synthesis and Antimalarial Activity”, Bioorganic & Medicinal Chemistry Letters, vol. 5, No. 16, pp. 1791-1794 (1995).

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