Antioxidant responsive element

Details Antioxidant responsive element Antioxidant responsive element

1997-05-23

2000-09-19

Guzo, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 241, 435455, 435325, 435375, 4353201, C12Q 168, C07H 2104

Patent

active

061209945

ABSTRACT:
The present invention relates, in general, to antioxidant responsive elements (AREs). In particular, the present invention relates to a DNA construct comprising an ARE having the DNA sequence 5'-RGR AC NNN GCT-3' (SEQ ID NO: 1) operably linked to a heterologous protein coding sequence; cells and non-human organisms comprising the DNA construct; a method of screening for a compound that increases transcription of an MRNA regulated by an antioxidant responsive element; and a purified compound that binds to an antioxidant responsive element.

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