Antioxidant nitroxides and nitrones as therapeutic agents

Details Antioxidant nitroxides and nitrones as therapeutic agents Antioxidant nitroxides and nitrones as therapeutic agents

2005-02-08

2005-02-08

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C514S638000

Reexamination Certificate

active

06852889

ABSTRACT:
The invention provides novel adamantane compounds having one of the following formulas:wherein:R1and R3are H, OH, alkyl, cycloalkyl, amino or aryl, and can be the same or different;R2is H, NH2, alkyl, OH, COOH, amino, amide, or carbamate;R4-R8are H, OH, NH2, alkyl, OH, COOH, ester, amino, amide, or alkyloxy, and can be the same or different;R9-R14are H, alkyl, or phenyl, and can be the same or different;and wherein when any of R1-R8is amino, the compounds are the free bases and their acid addition salts.The present invention also relates to compositions and methods for treating and/or preventing neurological and inflammatory disorders in a patient by administering a therapeutically effective amount of the compounds of formula (I), (II) or (III) and a pharmaceutically acceptable carrier.

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