Antioxidant-induced apoptosis in vascular smooth muscle cells

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61F 202

Patent

active

055715230

ABSTRACT:
A method of inhibiting arteriosclerosis or smooth muscle cell proliferation by identifying an animal having an artery suspected of needing such inhibition and contacting the artery with an apoptosis-inducing amount of an antioxidant.

REFERENCES:
patent: 5464833 (1995-11-01), Nakai et al.
Abello et al., "Antioxidants Modulate Induction of Programmed Endothelial Cell Death (Apoptosis) by Endotoxin", 1994, Arch. Surg., 129:134-41.
Garcia et al., "Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene," 1992, Science, vol. 258.
Gavrieli et al., "Identification of Programmed Cell Death In Situ via Specific Labeling of Nuclear DNA Fragmentation," 1992, J. Cell Biology, 119:(3):493-501.
Gerschenson et al., "Apoptosis: A Different Type Of Cell Death," Apr. 1992, Faseb J., 6:2450.
Hockenberry et al., "BCL2 Protein Is Topographically Restricted in Tissues Characterized By Apoptotic Cell Death," 1991, Cell Biology, 88:6961-6965.
Jacobson et al., "Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA," 1993, Nature, vol. 361.
Kane et al., "Bcl-2 Inhibition of Neural Death: Decreased Generation of Reactive Oxygen Species," 1993, Science, vol. 262.
Louis et al., "CMTF Protection of Oligodendrocytes Against Natural and Tumor Necrosis Factor--Induced Death," 1993, Science, vol. 259.
Meikrantz et al., "Activation of Cyclin A-Dependent Protein Kinases During Apoptosis," 1994, Proc. Natl. Acad. Sci. USA, 91:3754-3758.
Plump et al., "Severe Hypercholesterolemia and Atherosclerosis in Apolipoprotein E-Deficient Mice Created by Homologous Recombination in ES Cells," 1992, Cell, 71:343-353.
Rothstein et al., "Chronic Inhibition of Superoxide Dismutase Produces Apoptotic Death of Spinal Neurons," 1994, Neurobiology, 91:4155-4159.
Schwartzman et al., "Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death," 1993, Endocrine Reviews, 14(2):133.
Tsai et al., "Promotion of Vascular Smooth Muscle Cell Growth By Homocysteine: A Link To Atherosclerosis," 1994, Proc. Natl. Acad. Sci. USA, 91:6369-6973.
White, "Death-Defying Acts: A Meeting Review on Apoptosis," 1993, Genes & Development 7:2277-2284.
Williams et al., "Molecular Regulation of Apoptosis: Genetic Controls on Cell Death," 1993, Cell, 74:777-779.
Wyllie, "Death get a brake," 1994, Nature, vol. 369.
Zhang, et al., "Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E," 1992, Science, 258:468-473.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antioxidant-induced apoptosis in vascular smooth muscle cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antioxidant-induced apoptosis in vascular smooth muscle cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antioxidant-induced apoptosis in vascular smooth muscle cells will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2013249

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.