Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1996-03-13
1999-07-06
Bawa, Raj
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424451, 424464, 424489, 514456, 514725, 514962, A61K 946
Patent
active
059194839
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to an antioxidant-containing effervescent composition
PRIOR ART
Antioxidants such as carotin, vitamin E, catechin or the like have been known to show activities, when combining with radicals occurring in vivo, of stabilizing the radicals, terminating the chain reaction of radicals in vivo (radical scavenger activity), and inhibiting the catabolism of organism-constituting protein and the like (antioxidation activity), thereby preventing carcinogenesis (anti-cancer activity). Recently, it has been reported that antioxidants also have an activity of hindering sunburn from developing by exposure to ultraviolet and an immunopotentiating activity. Attention is now focused on antioxidants useful as food materials and pharmaceutical materials in view of the current health food-oriented trend.
However, antioxidants are difficult to make into an effervescent preparation because of their solubility and stability to air (oxygen), light, heat, etc.
An object of the present invention is to provide a novel preparation, particularly a novel effervescent composition, which uniformly and stably contains said antioxidant and which is excellent in solubility.
DISCLOSURE OF THE INVENTION
The inventors of the present invention conducted extensive research and found that the foregoing object can be achieved by an effervescent composition containing the undermentioned specific antioxidant-containing powder. The present invention has been accomplished based on this novel finding.
According to the present invention, there is provided an antioxidant-containing effervescent composition comprising, as essential components: antioxidant-containing powder containing 0.2 to 20% (based on the antioxidant-containing powder) of an antioxidant (fat-soluble substance) on the catechin-containing powder) of a water-soluble antioxidant!,
According to the inventions there are also provided said antioxidant-containing effervescent composition comprising, as essential components, 0.1 to 5.0% of an antioxidant-containing powder containing 0.5 to 10% (based on the antioxidant-containing powder) of an antioxidant (fat-soluble substance), 20 to 30% of sodium hydrogencarbonate and/or sodium carbonate, 10 to 40% of a neutralizing agent and 30 to 55% of an excipient; said antioxidant-containing effervescent composition, wherein the neutralizing agent is selected from malic acid, tartaric acid, citric acid and ascorbic acid; said antioxidant-containing effervescent composition, wherein the excipient is a carbohydrate selected from maltitol, sorbitol and maltose; and said antioxidant-containing effervescent composition, wherein said antioxidant is at least one member selected from the group consisting of carotin, vitamin E and catechin.
The antioxidant-containing effervescent composition of the present invention has features that the composition is capable of satisfactorily preventing the properties of the antioxidant from degrading due to oxidation and shows high solubility even in cold water.
The composition of the present invention will be described below in more detail. The antioxidant-containing powder as one of the essential components of said effervescent composition includes, for example, powders containing carotin, vitamin E, catechin or the like as an antioxidant. The carotin is a precursor of vitamin A and has a provitamin A activity Useful carotins include .alpha.-, .beta.- and .gamma.-carotins. The vitamin E can be any of .alpha.-, .beta.-, .gamma.- and .delta.-tocopherol. Said species of carotin and vitamin E, whether they are natural or synthetic, can be advantageously used in the practice of the invention. Typical examples of catechins are epigallocatechin gallates (EGCg), epicatechin gallates (ECg), epigallocatechins (EGC) and epicatechins (EC), such as tea polyphenol, apple polyphenol and the like.
Of the antioxidant-containing powders, powders containing carotin, vitamin E or like fat-soluble substances include, for example, those having a matrix comprising said antioxidant dissolved in
REFERENCES:
Derwent Abstract of JP-A-59 166 585 (1984).
Matsumoto Toshiaki
Okamoto Toshihiko
Takaichi Akihisa
Bawa Raj
Otsuka Pharmaceutical Co. Ltd.
LandOfFree
Antioxidant-containing effervescent composition does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antioxidant-containing effervescent composition, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antioxidant-containing effervescent composition will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-897408