Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-08-16
2011-08-16
Menon, Krishnan S (Department: 1777)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C424S729000, C424S766000, C514S027000, C514S904000, C514S458000, C422S068100
Reexamination Certificate
active
07999003
ABSTRACT:
The present invention provides a performance assay that measures the total antioxidant activity of a composition using oxygen uptake in contrast to prior art methods that measure antioxidant capacity by indirectly measuring degradation of a fluorescent compound by following the disappearance of fluorescence. Using the performance antioxidant assay of the present invention, an antioxidant composition having synergistic activity is provided by the present inventors that includes flavonoids such as the flavonol quercetin, mixed tocopherols or tocotrienols, grape skin extract, green tea extract and bush plum. The antioxidant activity of the present composition exceeds 6,000 micromoles Trolox equivalent units per gram using the present invention.
REFERENCES:
patent: 5427951 (1995-06-01), Davies et al.
patent: 6063403 (2000-05-01), de Haan et al.
patent: 6086910 (2000-07-01), Howard et al.
patent: 6114177 (2000-09-01), Naguib
patent: 6177260 (2001-01-01), Benzie et al.
patent: 6231877 (2001-05-01), Vacher et al.
patent: 6291533 (2001-09-01), Fleischner
patent: 6365622 (2002-04-01), Cavazza
patent: 6429021 (2002-08-01), Qian et al.
patent: 6562869 (2003-05-01), Hamilton et al.
patent: 6607919 (2003-08-01), Popv et al.
patent: 6642277 (2003-11-01), Howard et al.
patent: 6805880 (2004-10-01), Højgaard et al.
patent: 2002/0182736 (2002-12-01), Aldini et al.
patent: 2002/0192314 (2002-12-01), Cho et al.
Brand, Jennie C. et al., An Outstanding Food Source of Vitamin C, 1982, The Lancet, vol. 320 Issue 8303, p. 873.
AlSheikhly et al., “Chain-Propagation Length of Linoleic Acid Peroxidation in Aqueous Monomeric and Micellar Systems”, J. Phys. Chem. (1989), vol. 93, pp. 3103-3106.
Barclay et al., “Benzophenone-photosensitized autoxidation of linoleate in solution and sodium dodecyl sulfate micelles”, Can. J. Chem. (1987), vol. 65, p. 2529-2540.
Burton et al., “Autoxidation of Biological Molecules. 1. The Antioxidant Activity of Vitamin E and Related Chain-Breaking Phenolic Antioxidants in Vitro”, J. Am. Chem. Soc. (1981), vol. 103, pp. 6472-6477.
Cao et al., “Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables,” Am. J. Clin. Nutr. (1998), vol. 68, pp. 1081-1087.
Castle et al., “Inhibition Kinetics of Chain-Breaking Phenolic Antioxidants in SDS Micelles. Evidence That Intermicellar Diffusion Rates May Be Rate-Limiting for Hydrophobic Inhibitors Such as α-Tocopherol”, J. Am. Chem. Soc. (1986), vol. 108, pp. 6381-6382.
Cosgrove et al. “The Kinetics of the Autoxidation of Polyunsaturated Fatty Acids”, Lipids (1987), vol. 22, pp. 299-304.
Halliwell et al., “Free Radicals in Biology and Medicine,” Oxford University Press, 2001, pp. 55-72.
Huang et al., “Development and Validation of Oxygen Radical Absorbance Capacity Assay for Lipophilic Antioxidants Using Randomly Methylated β-Cyclodextrin as the Solubility Enhancer,” J. Agric. Food Chem. (2002), vol. 50, pp. 1815-1821.
Niki et al., “Inhibition of Oxidation of Methyl Linoleate in Solution by Vitamin E and Vitamin C”, J. Biol. Chem. (1984), vol. 259, pp. 4177-4182.
Ou et al., “Development and Validation of an Improved Oxygen Radical Absorbance Capacity Assay Using Fluorescein as the Fluorescent Probe,” J. Agric. Food Chem. (2001), vol. 49, pp. 4619-4626.
Packer et al., “Direct observation of a free radical interaction between vitamin E and vitamin C,” Nature (1979), vol. 278, pp. 737-738.
Pryor et al., “A Rapid Screening Test to Determine the Antioxidant Potencies of Natural and Synthetic Antioxidants”, J. Org. Chem. (1993), vol. 58, pp. 3521-3532.
Pryor et al., Comparison of the Efficiencies of Several Natural and Synthetic Antioxidants in Aqueous Sodium Dodecyl Sulfate Micelle Solutions, J. Am. Chem. Soc. (1988), vol. 110, pp. 2224-2229.
Pryor et al., “Autoxidation of Micelle-Solubilized Linoleic Acid. Relative Inhibitory Efficiencies of Ascorbate and Ascorbyl Palmitate”, J. Org. Chem., (1985), vol. 50, pp. 281-283.
Yilmaz et al., “Reaction of β-carotene and AAPH in phosphate buffer during the oxygen radical absorbance capacity (ORAC) assay,” Food Science and Technology (2001).
International Search Report issued Mar. 29, 2005, in connection with International Application No. PCT/US2004/027644.
Written Opinion of the International Searching Authority issued Mar. 29, 2005, in connection with International Application No. PCT/US2004/027644.
International Preliminary Report on Patentability issued Aug. 15, 2005 in connection with International Application No. PCT/US2004/027644.
International Search Report issued Sep. 12, 2005, in connection with International Application No. PCT/US05/06924.
Written Opinion of the International Searching Authority issued Sep. 12, 2005, in connection with International Application No. PCT/US05/06924.
Koepke C. Michael
McAnalley Bill H.
McAnalley Shayne A.
Vennum Eileen
Chalker Daniel J.
Chalker Flores LLP
Flores Edwin S.
Fritchman Rebecca
Mannatech, Incorporated
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