Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...
Reexamination Certificate
2008-05-13
2008-05-13
Hoffman, Susan Coe (Department: 1655)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Reexamination Certificate
active
07371413
ABSTRACT:
The present invention provides methods for reducing the production of nitric oxide, inducible nitric oxide synthase protein and mRNA, and cyclooxygenase-2 protein and mRNA in cells both in vivo and in vitro via the administration of extracts and compounds derived from the seeds ofPycnanthus angolensisWarb. (P. Kombo), commonly known as African nutmeg. These extracts and compounds, namely,kombobutter,kombobutter acid extract, sargaquinoic acid, sargachromenol, and sargahydroquinoic acid, are also useful in the treatment and prevention of a battery of adverse health conditions in human, animal, and avian subjects that are advanced by the production of nitric oxide or its metabolites and/or by the activity of cyclooxygenase-2. Methods for the isolation ofkombobutter acid extracts are also provided.
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Acquaye Daniel Fahene
Asianowa Yaw
Gbewonyo Kodzo
Rafi Mohamed M.
Simon James E.
BioResources International Inc.
Genieser Lars H.
Gollin Michael A.
Hoffman Susan Coe
Rutgers The State University
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