Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-04-11
1998-09-08
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, A61K 3801, C07K 1479
Patent
active
058045554
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to an antioxidant. More particularly, the present invention relates to a safe antioxidant applicable for food, drug medicine, non-medical drug and other products.
BACKGROUND ART
Oils and fats are oxidized by oxygen contained in the atmosphere, thus producing peroxides. Peroxides are relatively unstable and further produce carbonyl and other compounds through polymerization and decomposition. These carbonyl and other compounds form major ingredients causing bad odor.
Peroxides and other compounds such as carbonyl cause deterioration of flavor and degradation of quality of oils and fats, and in addition, these peroxides, when absorbed, exert detrimental effects in vivo. In an experiment in which a large dose of a lipid peroxide was administered to animals during a short period of time, peroxide have been clarified to induce troubles in the liver function and the immune system.
Oxidation reactions in vivo are known to relate to aging and various diseases. More specifically, active oxygen produced in vivo oxidizes lipid rich in unsaturated fatty acid, causes progress of radical linkage peroxidizing reaction, and produces peroxidized lipid such as lipid hydroperoxide. Decomposition of lipid hydroperoxide produces active oxygen species such as highly reactive alkoxy radical, peroxy radical, and singlet oxygen, thus causing progress of linkage reactions.
Free radicals and active oxygen species generated in the course of oxidation reaction denature protein in vivo, inactivate enzymes, bring about mutation in DNA, and finally cause various diseases including aging and cancer.
Many substances are known to have antioxidant action, including for example having a metal chelating function (Kajimoto and Yoshida: Yukagaku, Vol. 21, p. 200, 1972), dipeptide (Yamaguchi, et al.: Journal of the Japan Food Industry Association, Vol. 22, p. 425, 1975), and a certain peptide available by enzymatic decomposition of egg albumin (Tsuge, et al.: Journal of the Agricultural Chemical Society of Lapan, Vol. 65, p. 1635, 1991).
Regarding lactoferrins which are natural iron-binding proteins contained in lacrima, saliva, peripheral blood, and milk of mammals, there is known the inhibiting effect of generation of iron-dependent peroxidized lipid and an anti-aging food product based on blending of lactoferrin is proposed (Japanese Patent Provisional Publication No. 4-58,871).
However, the antioxidant action of a hydrolysate of lactoferrins or of a peptide in such a hydrolysate has not as yet been known at all, and there has been present no antioxidant containing them as an effective ingredient.
DISCLOSURE OF INVENTION
The present invention has an object to provide a safe antioxidant containing, unlike the conventional antioxidants, a hydrolysate of lactoferrins, and/or peptide in the hydrolysate as effective ingredients.
The present invention provides an antioxidant, of which an effective ingredient is an antioxidant substance selected from the group consisting of a hydrolysate of lactoferrins, one or more peptides isolated from a hydrolysate of lactoferrins, one or more synthetic peptides having the same amino acid sequence as that of the peptide isolated from the hydrolysate of lactoferrins, and any mixture thereof.
The present invention provides also an antioxidant containing, as effective ingredients, an oxidation preventive agent and an antioxidant substance selected from the group consisting of a hydrolysate of lactoferrins, one or more peptides isolated from a hydrolysate of lactoferrins, one or more synthetic peptides having the same amino acid sequence as that of the peptide isolated from the hydrolysate of lactoferrins, and any mixture thereof.
This antioxidant has an excellent antioxidant action for various lipids, and is very safe even when used in foods and drug medicine. Since it exhibits antioxidant effect with only a small quantity, there is almost no adverse effect on flavor even when applied in foods.
BEST MODE FOR CARRYING OUT THE INVENTION
In the present invention,
REFERENCES:
(Abstract) WO 92/09628, Immunodynamics, PCT Whole Document, Jun. 11, 1992.
(Abstract) EP 474506, Tomita et al., EP Whole Document, Mar. 11, 1992.
Halliwell "Drug Antioxidant Effects . . . ", Drugs (1991) V. 42 No. 4, pp. 569-605.
Rejman, " Bovine Lactoferrin . . . " (1989) (ABS Only) Medline AB #90:031466.
Bellamy Wayne Robert
Fukuwatari Yasuo
Kawase Kouzo
Shimamura Seiichi
Takase Mitsunori
Delaney Patrick R.
Morinaga Milk Industry Co. Ltd.
Tsang Cecilia J.
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