Antiosteoporotic agents

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Allergen or component thereof

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A61K 3138

Patent

active

041016688

ABSTRACT:
It is disclosed that compounds of the formula: ##STR1## WHEREIN Y represents (C.dbd.O).sub.m in which m has a value of 0 or 1; n has a value of 0 or 1; and X represents S, NH or O; provided that there is a COOH substituent at the 1, 2 or 3 position relative to the X group; and further provided that when X is NH and n is O, the COOH group cannot be at the 2 position; and further provided that when n is 0, the carboxyl group is attached to the ring containing the X and Y ring members or a nontoxic, pharmaceutically acceptable salt thereof are capable of decreasing the ratio of the rates of bone resportion to bone deposition in a host animal, e.g., in the treatment of osteoporosis.

REFERENCES:
patent: 3655697 (1972-04-01), Shen et al.
patent: 3674875 (1972-07-01), Shen et al.
patent: 3784602 (1974-01-01), Frei et al.
patent: 3803180 (1974-04-01), Berger et al.
patent: 3953601 (1976-04-01), Bondesson et al.
patent: 3975403 (1976-08-01), Gante et al.

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