Antineoplastic use and pharmaceutical compositions containing th

Details Antineoplastic use and pharmaceutical compositions containing th Antineoplastic use and pharmaceutical compositions containing th

1996-07-23

1998-10-13

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549510, 549511, C07D26304, C07D41312, C07D30514

Patent

active

058213635

DESCRIPTION:

BRIEF SUMMARY
BACKGROUND OF THE INVENTION

Taxol is a member of the taxane family of diterpenes, having the structure shown below: ##STR2## The numbering system shown for taxol is that recommended by IUPAC (IUPAC, Commission on the Nomenclature of Organic Chemistry, 1978).
The chemistry of the potent anticancer diterpenoid taxol and analogs thereof is reviewed, with an emphasis on isolation and analysis, structural modifications, partial synthesis, and structure-activity relationships by David G. I. Kingston, The Chemistry of Taxol, Pharmac. Ther., Vol 52, pp 1-34, 1991.
The clinical pharmacology of taxol is reviewed by Eric K. Rowinsky and Ross C. Donehower, The Clinical Pharmacology and Use of Antimicrotubule Agents in Cancer Chemotherapeutics, Pharmac. Ther., Vol 52, pp 35-84, 1991. Clinical and preclinical studies with taxol are reviewed by William J. Slichenmyer and Daniel D. Von Hoff, Taxol: A New and Effective Anti-cancer Drug, Anti-Cancer Drugs, Vol. 2, pp 519-530, 1991.
Taxol and analogs thereof are the subject of various patents including, for example, U.S. Pat. Nos. 4,814,470; 4,857,653; 4,942,184; 4,924,011; 4,924,012; 4,960,790; 5,015,744; 5,157,049; 5,059,699; 5,136,060; 4,876,399; 5,227,400, 5,248,796 as well as PCT Publication No. WO 92/09589, European Patent Application 90305845.1 (Publication No. A2 0 400 971), 90312366.9 (Publication No. A1 0 428 376), 89400935.6 (Publication No. A1 0 366 841) and 90402333.0 (Publication No. 0 414 610 A1), 87401669.4 (A1 0 253 739), 92308608.6 (A1 0 534 708), 92308609.4 (A1 534 709) and PCT Publication Nos. WO 91/17977, WO 91/17976, WO 91/13066, WO 91/13053.
Various processes for the preparation of taxol (and intermediates and analogs thereof) are described in Tetrahedron Letters, 1992, 33, 5185; J. Org. Chem., 1991, 56, 1681 and J. Org. Chem., 1991, 56, 5114 as well as WO 94/07876, WO 94/07877, WO 94/07878 and WO 94/07879. See also U.S. Pat. No. 4,924,011 (and Reissue Patent 34,277, dated 8 Jun. 1993) as well as Tetrahedron Letters 35, 4483 (1994).
Chen et al., Serendipitous Synthesis of a Cyclopropane-Containing Taxol Analog via Anchimeric Participation of an Unactivated Angular Methyl Group, Advance ACS Abstracts, Vol 1, No. 2., Jul. 15, 1993 reported the treatment of a 7-epi taxol derivative with DAST in dichloromethane led to an unexpected reaction involving participation of the C-19 methyl group and clean formation of a cyclopropane ring. See also J. Org. Chem., 1993, 58, 4520 (Aug. 13, 1993) and U.S. Pat. No. 5,254,580 (granted 19 Oct. 1993).
U.S. Pat. No. 5,248,796 (granted 28 Sep. 1993) relates to 10-desacetoxy-11,12-dihydrotaxol-10,12(18)-diene derivatives and the preparation of 10-desacetoxytaxol.
EP Application 0 558 959 A1 discloses various phosphonooxy and carbonate 2' taxol derivatives of taxol with increased water solubility.
Water-soluble pro-taxol analogs are disclosed in Nicolaou, K. C.; Riemer, C.; Kerr, M. A.; Rideout, D.; Wrasidlo, W., Nature 364:464-66 (1993).
C-2 substituted benzoate analogs of taxol and their synthesis is described in J. Am. Chem. Soc. 1994, 116, 4097-98 and Bioorganic & Medical Chemistry Letters, Vol. 4, No. 3, 479-82, 1994.


SUMMARY OF THE INVENTION

This invention provides .DELTA..sup.12,13 -iso-taxol analogs of Formula I: ##STR3##
The compounds of Formula I are useful for the treatment of the same cancers for which taxol has been shown active, including human ovarian cancer, breast cancer, and malignant melanoma as well as lung cancer, gastric cancer, colon cancer, head and neck cancer, and leukemia.


CONVENTIONS FOR FORMULAS AND DEFINITIONS OF VARIABLES

The chemical formulas representing various compounds or molecular fragments in the specification and claims may contain variable substituents in addition to expressly defined structural features. These variable substituents are identified by a letter or a letter followed by a numerical subscript, for example, "Z.sub.1 " or "R.sub.i " where "i" is an integer. These variable substituents are either monovalent or bivalent, that is, they represent a group attached to the fo

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