Antineoplastic, system - L specific amino acid nitrogen mustards

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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562456, A61K 31195

Patent

active

047726326

ABSTRACT:
New antineoplastic, system - L specific amino acid nitrogen mustards with reduced myelosuppressive effect are disclosed. A method for identifying and isolating the cellular component comprising the L - amino acid transport system is also described.

REFERENCES:
patent: 3532744 (1970-10-01), Fletcher et al.
patent: 3704312 (1972-11-01), Russell et al.
Conners et al., J. Chem. Soc., pp. 2994-3007 (1960).
Kilberg Federation Proceedings 45:2483-2454, "Amino Acid Transport in Eukaryotic Cells and Tissues", 1986.
Mauger et al., Biochemical Pharmacology 11:847-858, "ARL-2-Halogenoalkylamines-XX", 1962.

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