Antineoplastic, system-L specific amino acid nitrogen mustards

Details Antineoplastic, system-L specific amino acid nitrogen mustards Antineoplastic, system-L specific amino acid nitrogen mustards

1991-11-15

1994-02-08

Alexander, Lyle A.

Chemistry: analytical and immunological testing

Biological cellular material tested

435 29, 436 64, G01N 33543

Patent

active

052847748

ABSTRACT:
New antineoplastic, system - L specific amino acid nitrogen mustards with reduced myelosuppressive effect are disclosed. A method for identifying and isolating the cellular component comprising the L - amino acid transport system is also described.

REFERENCES:
patent: 4772632 (1987-02-01), Vistica
Frankfurt, Exp. Cell Res. 170(1987) 369-380.
Connors et al., J. Pharm. Exp. Therap., 1943, 77, 175.
Mauger et al., Biochemical Pharmocology (1962) vol. 11, pp. 847-858.
Killberg, Federation Proceedings 45:2483-2454 "Amino Acid Transport in Eukaryotic Cells and Tissues", 1986.

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