Antineoplastic solution and method for treating neoplasms

Details Antineoplastic solution and method for treating neoplasms Antineoplastic solution and method for treating neoplasms

1991-09-20

1992-11-10

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424 11, 424422, 424424, 424425, 424426, 424427, 424428, 424405, 514937, A61K 908, A61K 4300, A61K 4506, A01N 2502

Patent

active

051621150

ABSTRACT:
Disclosed are antineoplastic for direct intratumoral delivery. The solutions are formulated using antineoplastic solutions agents dissolved in organic, water miscible, solvent vehicles. The vehicle is selected such that a) the agent is dissolved in the vehicle, b) the agent is stable and bioavailable in the vehicle, and c) the vehicle readily diffuses through and permeates tumorous tissue. The solution is injected directly into the tumor and, as the vehicle permeates the tumor tissue it transports the agent therewith. In this way therapeutically effective levels of antineoplastic agent are effectively and rapidly delivered and disseminated into the tumor mass with little or no dissemination into surrounding healthy tissue.

REFERENCES:
patent: 5051257 (1991-09-01), Pietronigro

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