Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1989-05-09
1991-09-24
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424422, 424426, 424428, A61F 200, A61F 908, A61F 202
Patent
active
050512579
ABSTRACT:
Disclosed are antineoplastic solutions for direct intratumoral delivery. The solutions are formulated using antineoplastic agents dissolved in organic, water miscible, solvent vehicles. The vehicle is selected such that a) the agent is dissolved in the vehicle, b) the agent is stable and bioavailable in the vehicle, and c) the vehicle readily diffuses through and permeates tumorous tissue. The solution is injected directly into the tumor and, as the vehicle permeates the tumor tissue it transports the agent therewith. In this way therapeutically effective levels of antinoeplastic agent are effectively and rapidly delivered and disseminated into the tumor mass with little or no dissemination into surrounding healthy tissue.
REFERENCES:
patent: 4300557 (1981-11-01), Refojo et al.
patent: 4536387 (1985-08-01), Sakamoto et al.
patent: 4558690 (1985-12-01), Joyce
patent: 4797282 (1989-01-01), Wahlig et al.
"Chemotherapy of an Experimental Glioma with Nitrosoureas", Tator et al., Cancer Research 27 (2/77), pp. 476-481.
"Comparison of Lipid-Mediated Blood-Brain-Barrier Penetrability in Neonates and Adults", Cornford et al., American Journal of Physiology 243 (1982), pp. C161-C168.
"Topical Carmustine Therapy for Lymphomatoid Papulosis", Zackheim et al., Arch. of Dermatology 121 (11/85), pp. 1410-1414.
"Fine Needle Percutaneous Intratumoral Chemotherapy Under Ultrasound Guidance: A Feasibility Study", Livraghi et al., Tumori 72 (1986) pp. 81-87.
"Effect of Difluoroemthylomithine on the Artiglioma Therapeutic Efficacy of Intra-Arterial BONU".
Cohen et al., Journal of Neurosurgery 65 (11/86), pp. 671-678.
"US-Guided Percutaneous Alcohol Injection of Small Hepatic and Abdominal Tumors", Livraghi et al., Radiology 161 (11/86), pp. 309-312.
"Treatment of Experimental Adenocarcinomas by Percutaneous Intratumoral Injection of Absolute Ethanol"., Burgener et al., Investigative Radiology 22 (6/87), pp. 472-478.
"Inhibition of Acquired Immune Deficiency Syndrome Virus by Oligodeoxynucleoside Methylphosphonates", Sarin et al., Proc. Natl. Acad. Sci. U.S.A. 85 (10/88), pp. 7448-7451.
Page Thurman K.
Spear James M.
LandOfFree
Antineoplastic solution and method for treating neoplasms does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antineoplastic solution and method for treating neoplasms, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antineoplastic solution and method for treating neoplasms will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1695416