Antineoplastic pyrrolo[4,3,2-de]quinolin-8(1H)-ones

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514292, 546 64, 546 84, A61K 3144, C07D47100

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active

054140013

ABSTRACT:
The invention discloses certain antitumor pyrrolo[4,3,2-de]quinolin-8(1H)-ones isolated from the Fijian marine sponge Z. cf. marsailis and structurally modified compounds thereof and pharmaceutical compositions.

REFERENCES:
Sun, H. H.; Sakemi, S.; Burres, N.; McCarthy, P. "J. Org. Chem.", 1990, 55, 4964.
Sakemi, S.; Sun, H.; Jefford, C. W.; Bernardinelli, G. "Tetrahedron Lett." 1989, 30, 2517.
Stierle, D. B.; Faulkner, D. J. "J. Nat. Prod.", 1991, 54, 1131.
Kobayashi, J.; Cheng, J.; Ishibashi, M.; Nakamura, H.; Ohizumi, Y.; Hirata, Y.; Sasaki, T.; Lu, H.; Clardy, J. "Tetrahedron Lett." 1987, 28, 4939.
Cheng, J.; Ohizumi, Y.; Walchli, M. R.; Nakamura, H.; Hirata, Y.; Sasaki, T.; Kobayashi, J. "J. Org. Chem." 1988, 53, 4621.
Kobayashi, J.; Cheng, J.; Yamamura, S.; Ishibashi, M. "Tetrahedron Lett." 1991, 32, 1227.
Kobayashi et al, Tetrahedron Letters, 32(9) pp. 1227-1228, 1991.

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