Antineoplastic peptides

Details Antineoplastic peptides Antineoplastic peptides

2005-07-11

2008-05-06

Epperson, Jon D. (Department: 1639)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Peptides with at least one nonpeptide bond other than a...

C530S330000

Reexamination Certificate

active

07368528

ABSTRACT:
The present invention provides antineoplastic peptides of formula I,in-line-formulae description="In-line Formulae" end="lead"?R1R2N—CHX—CO-A-B-D-E-(G)s-K Iin-line-formulae description="In-line Formulae" end="tail"?wherein R1, R2, X, A, B, D, E, G, K, and s have the meanings stated in the description. The compounds have antineoplastic activity.

REFERENCES:
patent: 4816444 (1989-03-01), Pettit et al.
patent: 5502032 (1996-03-01), Haupt et al.
patent: 5504191 (1996-04-01), Pettit et al.
patent: 5530097 (1996-06-01), Pettit et al.
patent: 5554725 (1996-09-01), Pettit
patent: 5831002 (1998-11-01), Haupt et al.
patent: 5864012 (1999-01-01), Amberg et al.
patent: 5886147 (1999-03-01), Amberg et al.
patent: 5965700 (1999-10-01), Amberg et al.
patent: 6015790 (2000-01-01), Barlozzari et al.
patent: 6103698 (2000-08-01), Barlozzari et al.
patent: 6143721 (2000-11-01), Janssen et al.
patent: 6248865 (2001-06-01), Amberg et al.
patent: 6458765 (2002-10-01), Janssen et al.
patent: 6632795 (2003-10-01), Barlozzari et al.
patent: 2003/0153505 (2003-08-01), Janssen et al.
patent: 4415997 (1995-11-01), None
patent: 0398558 (1990-11-01), None
patent: 0598129 (1994-05-01), None
patent: WO-92/02541 (1992-02-01), None
patent: WO-93/23424 (1993-11-01), None
patent: WO-95/30690 (1995-11-01), None
patent: WO-95/30691 (1995-11-01), None
patent: WO-96/40751 (1996-12-01), None
patent: WO-96/40752 (1996-12-01), None
patent: WO-97/17364 (1997-05-01), None
Tasidotin HCI Genzyme, 2005, Current Opinion in Investigational Drugs, 6(6): 631-638.
Pettit, G.R., et al., “The Isolation and Structure of a Remarkable Marine Animal Antineoplastic Constituent: Dolastatin 10,”J. Am. Chem. Soc., vol. 109:6883-6885 (1987).
Bai, R., et al., “Structure-Activity Studies with Chiral Isomers and with Segments of teh Antimitotic Marine Peptide Dolastatin 10,”Biochemical Pharmacology, vol. 40(8):1859-1864 (1990).
Pettit, G.R., et al., “Antineoplastic Agents. 220. Synthesis of Natural (-)—Dolastatin 15,”J. Chem. Soc., vol. 113:6692-6693 (1991).
Bai, R., et al., “Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects on cellular microtubules,”Biochemical Pharmacology, vol. 43: 2637-2645 (1992).
Pettit, G.R., et al., “Isolation and Structure of the Cytostatic Depsipeptide Dolastatin 13 from the Sea Hare Dolabella auricularia,”J. Am. Chem. Soc., vol. 111(13):5015-5017 (1989).
Pettit, G.R., et al., “Antineoplastic Agents 337. Synthesis of Dolastatin-10 Structural Modifications,”Anti-Cancer Drug Design, vol. 10:529-544 (1995).
Miyazaki, K., et al., “Synthesis and Antihumor Activity of Novel Dolastatin-10 Analogs,”Chem. Pharm. Bull., vol. 43(10):1706-1718 (1995).
Pettit, G.R., et al., “Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15,”J. Org. Chem. vol. 54:6005-6006 (1989).
Pettit, G.R., et al., “The Dolastatins 20. A convenient synthetic route to Dolastatin 15,”Tetrahedron, vol. 50(42):12097-12108 (1994).
Pettit, G.R., et al., “Isolation of Dolastatin 10-15 from the Marine Mollusc Dolabella Auricularia,”Tetrahedron, vol. 49(42):9151-9170 (1993).

Affiliated with

Also associated with

Rating

Antineoplastic peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antineoplastic peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antineoplastic peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3985763