Antineoplastic enamine derivatives of daunorubicin and adriamyci

Details Antineoplastic enamine derivatives of daunorubicin and adriamyci Antineoplastic enamine derivatives of daunorubicin and adriamyci

1987-01-12

1989-04-25

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1524

Patent

active

048249440

ABSTRACT:
The present invention relates to new enamine derivatives of daunorubicin and adriamycin of the formula l: ##STR1## and formula 2: ##STR2## wherein R denotes a hydrogen atom or hydroxyl group. The inventive compounds are useful antineoplastic antibiotics utilized in the treatment of cancer, primarily leukemia. The present derivatives demonstrate a reduction in toxicity, in particular cardiotoxicity, over their parent compounds, while retaining chemotherapeutic properties.

REFERENCES:
patent: 4591637 (1986-05-01), Acton et al.

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