Antineoplastic compounds and methods of using same

Details Antineoplastic compounds and methods of using same Antineoplastic compounds and methods of using same

1992-02-13

1993-09-21

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483024, A01N 4352, A61K 31415

Patent

active

052469557

ABSTRACT:
New cytotoxic quionones, designated amamitosenes and iminoazamitosenes are found to have significant activity against ovarian tumors, colon cancer, myecloma and the like neoplastic diseases.
Pharmaceutical preparations and therapeutic regimens utilizing azamitosenes and iminoazamitosenes and their pharmaceutically active derivatives are disclosed.

REFERENCES:
patent: 5015742 (1991-05-01), Skibo
Islam et al "Synthesis and Physical Studies of Azamitosene and Iminoazamitosene Reductive Alkylating Agents" J. Org. Chem. 1990, 55, 3195-3205.

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