Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-27
1999-10-05
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514242, 544182, 544313, 544314, 544312, 544311, C07D23954, C07D239553, A61K 31505
Patent
active
059624604
ABSTRACT:
The present invention provides antineoplastic .alpha.-methylene-.gamma.-butyrolactones represented by the general one or two groups selected from the group consisting of halide, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, phenyl, nitro and amino;.sub.2 R represents hydrogen, halide, (C.sub.1 -C.sub.4)alkyl or benzyl; X represents N; or wherein R.sub.1 is a phenyl group optionally substituted with one or two groups selected from the group consisting of halide, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4) alkoxy, nitro and amino; R.sub.2 represents Cl, F, or benzyl; X represents CH. These .alpha.-methylene-.gamma.-butyrolactones may be administered with an inert diluent or with a pharmaceutically acceptable carrier in controlling the growth of a neoplasm in a patient afflicted with a neoplasm disease. ##STR1##
REFERENCES:
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Huang, B. et al. Chemical Abstract, No. 116:128491, the abstract of Zhonghua Yaoxue Zazhi, vol. 43, pp. 447-455, published in 1991 (Mar. 1992).
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Cleton, F.J. Oxford Textbook of Oncology, vol. 1, ed. by Peckham, M. et al. (Oxford University Press, Oxford), pp. 445-453 (1995).
Chen Yeh-Long
Huang Bor-Ruey
Lee Kuan-Han
Tzeng Cherng-Chyi
Chang Chi Ping
Ford John M.
National Science Council (Taiwan)
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