Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2000-03-06
2003-06-24
Powers, Fiona T. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S453000
Reexamination Certificate
active
06583171
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to dithiolopyrrolone derivatives, their corresponding monoxides (xenomins) and dioxides (xenorxides) having antineoplastic activities. The present invention also provides antineoplastic compositions comprising these compounds, the salts thereof, and methods of using the inventive compounds as antineoplastic agents.
SUMMARY OF THE INVENTION
The present invention provides dithiolopyrrolone derivatives, their corresponding monoxides (xenomins) and dioxides (xenorxides) having antineoplastic activities. The present invention also provides antineoplastic compositions comprising these compounds, the salts thereof, and methods of using the inventive compounds as antineoplastic agents.
Compounds, xenorxides, isolated from the bacteria
Xenorhabdus bovienii
, have the formula
in which R
1
, R
2
hydrogen, substituted or unsubstituted alkyl, cycloally1, acyl, aryl, aralkyl, or heterocyclyl group; R
3
=hydrogen, alkyl, cycloalcyl, arallyl or aryl group or the salt thereof. These compounds have antineoplastic activity. The invention provides processes for producing these compounds. The invention also provides pharmaceutical compositions containing the compounds and the methods for treatment employing them.
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Chen Genhui
Li Jianxiong
Webster John Malcolm
Powers Fiona T.
Welichem Biotech Inc.
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