Antineoplastic agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S453000

Reexamination Certificate

active

06583171

ABSTRACT:

FIELD OF THE INVENTION
The present invention relates to dithiolopyrrolone derivatives, their corresponding monoxides (xenomins) and dioxides (xenorxides) having antineoplastic activities. The present invention also provides antineoplastic compositions comprising these compounds, the salts thereof, and methods of using the inventive compounds as antineoplastic agents.
SUMMARY OF THE INVENTION
The present invention provides dithiolopyrrolone derivatives, their corresponding monoxides (xenomins) and dioxides (xenorxides) having antineoplastic activities. The present invention also provides antineoplastic compositions comprising these compounds, the salts thereof, and methods of using the inventive compounds as antineoplastic agents.
Compounds, xenorxides, isolated from the bacteria
Xenorhabdus bovienii
, have the formula
in which R
1
, R
2
hydrogen, substituted or unsubstituted alkyl, cycloally1, acyl, aryl, aralkyl, or heterocyclyl group; R
3
=hydrogen, alkyl, cycloalcyl, arallyl or aryl group or the salt thereof. These compounds have antineoplastic activity. The invention provides processes for producing these compounds. The invention also provides pharmaceutical compositions containing the compounds and the methods for treatment employing them.


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