Antimycotic nail varnish

Drug – bio-affecting and body treating compositions – Manicure or pedicure compositions

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514345, 546290, A61K 7043

Patent

active

049577301

ABSTRACT:
A nail varnish comprising a water-insoluble film-forming substance and an antimycotic compound which is a 1-hydroxy-2-pyridone I of the general formula ##STR1## in which R.sup.1 is a hydrocarbon group which contains from 6 to 9 carbon atoms, but is free from olefinic and acetylenic bonds, one of the groups R.sup.2 and R.sup.4 is hydrogen and the other is hydrogen, methyl or ethyl and R.sup.3 is alkyl having up to two carbon atoms, said antimycotic ingredient being present in free form or in the form of a salt.

REFERENCES:
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patent: 3883545 (1975-05-01), Lohaus et al.
patent: 3968118 (1976-07-01), Lohaus et al.
patent: 4185106 (1980-01-01), Dittmar et al.
patent: 4250164 (1981-02-01), Bernstein
Dittmar et al., C.A., 92:47183b, Feb. 1980, No. 6.
Lohaus et al., Arzneimittel Forschung (Drug Research) 31, (II) 1981, pp. 1311-1316.
Fungiplex Nail Varnish, Prospectus of Hermal-Chemie Kurt Herrmann, Hamburg, Fed. Rep. of Germany.
O. Male, Therapie der Pilzkrankheiten, WMW Sonderheft 1/1983, pp. 27-34.
Aldrich, p. 860 (1988).
Kellner et al, Chem. Abstracts, 95, 225547v, (1981).

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