Antimycobacterial compounds and method of using same

Details Antimycobacterial compounds and method of using same Antimycobacterial compounds and method of using same

1996-12-13

1998-11-17

Cook, Rebecca

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514924, A61K 3120

Patent

active

058377328

ABSTRACT:
The present invention provides a compound having the structure: ##STR1## wherein R is a branched or unbranched C1-C30 alkyl, alkenyl or alkynl; or a branched or unbranched C1-C30 alkyl, alkenyl or alkynl substituted with S, O, N, P, SO.sub.2, F, Cl, Br, or I, wherein S, O, N, P, or SO.sub.2 replaces at least one --CH.sub.2 --, and F, Cl, Br, or I replaces at least one H. The present invention also provides a pharmaceutical composition comprising the compound above, as well as a method for treating a mycobacterial disease or infection in a subject in need of such treatment by administering to the subject an effective amount of the compound above.

REFERENCES:
"Inactivation of General Acyl-CoA Dehydrogenase from Pig Kidney by 2-Alkynoyl Coenzyme A Derivatives: Initial Aspects" by Freund, et al. Biochemistry 1985, 24, pp. 5996-6000, 6002.
Medne et al, News of the Latvian SSR Academy of Sciences 7(264) pp. 139-140, 1969.
Merck Manual, p. 126, 1987.
CA 95: 81103, Kuman et al, 1981.
CA 71: 99218, Medne et al, 1969.

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