Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-01-25
2005-01-25
McKane, Joseph K. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
06846933
ABSTRACT:
The present invention relates to novel antimycobacterial compounds and in particular to antimycobacterial compounds comprised of Schiff base, diacylhydrazine, sulfur-containing diacylhydrazine and oxadiazoline congeners of isonicotinic acid hydrazide. This invention further relates to processes for their preparation, to intermediates useful in their preparation, to their use as therapeutic agents and to pharmaceutical compositions containing them.
REFERENCES:
patent: 51032363 (1976-03-01), None
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Journal of Organic Chemistry, vol. 18, Synthetic Tuberculostats. V. Alkylidene Derivatives of Isonicotinylhydrazine, p. 983-989 (1953).*
CA 12508g, “Aldehyde hydrazone derivatives in cancer chemotherapy”, Wiley et. al., Vold. 58, 1963.*
Ca 14721c, “Aminooxides of physiologically active copounds. I. Aminooxides of isonicotinic acid derivatives.”, vol. 51, 1957.*
Jahresbericht 1954/55 Chemi des Isoniazids, Ekkehard Kruger-Thiemer, Entdeckungsgeschichte, pp. 192-197 (English Translation Enclosed); pp. 229-232 (English Translation Enclosed); pp. 303-319.*
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CA 13326a, “Gossypol and isonicotinoylhydrazogossypol as analytical reagents for the photocolorimetric determination of uranium”, Asamov et. al., vol. 59, 1964.*
CA 11458 f, “4-hydroxycoumarin derivatives wth anticoagulent activity. V. Condesation Products of aromatic dialdehydes with 4-hydroxycoumarin.”, Pazdro et. al., vol. 59, 1963.*
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Isonicotinoyl hydrazones and their antituberculous activity, Doklady Akad. Nauk S.S.s.R. 84, 981-4 (1952) (Abstract Only).
Antibacterial action of amphipathic derivates of isoniazid against the Mycobacterium avium complex, Zntralbl. Bakteriol, Mikrobiol. Hyg., Ser. A (1988), 268(4), 456-62 (Abstract Only).
Synthetic Tuberculostats. V. Alkylidene Derivatives of Isonicotinylhydrazine, Journal of Organic Chemistry, vol. 18, pp. 983-989 (1953).
Buu-Hoi et al., Tuberculostatic Hydrazides and their Derivatives, Journal of the Chemical Society, (278) 1358-1364 (1952).
Chemotherapy of Experimental Tuberculosis. VIII. The Synthesis of Acid Hydrazides, their Derivatives and Related Compounds, Journal of the American Chemical Society, pp. 1933-1942 (1953).
Stability and Antibacterial Effect of D-Glucuronolactone Isonicotinyl Hydrazone and Isoniazid, American Review of Tuberculosis of Puluronary Disease, vol. 73, 1956 (pp. 892-906).
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Fox, H.H. et al.: Synthetic tuberculostats. V. Alkylidene derivatives of isonicotinylhydrazine. J. Org. Chem. vol. 18, pp. 983-989, 1953, especially compounds in tables I, II and III on pp. 985 and 986.
Bottari, B. et al. Isoniazid-related copper (II) and nickel (II) complexes with antimycobacterial in vitro activity. Bioorgan. & Medicin. Chem. Lett. 2000, vol. 10, pp. 657-660, especially compounds 1a-1n in scheme 1 on p. 658.
Experimentelle vergleichende Untersuchung der tuberkulostatischen Wirksamkeit nd Toxizitat von INH, INHG and INHG-Na, pp. 409-416, Arzneim. Forsch., vol. 26, No. 3 (1976) (Abstract Only).
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Gauthier & Connors LLP
McKane Joseph K.
Robinson Binta
The Board of Trustees of Wellesley College
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