Antimutagenic agents

Details Antimutagenic agents Antimutagenic agents

1998-08-05

2000-03-28

MacMillan, Keith D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514335, 424266, 424251, 424270, A61K 31455, A61K 31505, A61K 31425

Patent

active

06043256&

ABSTRACT:
A method of treating a human subject to inhibit mutagenic effects of carcinogens by administering to the subject a composition comprising a sufficient amount of 6,6'-dithiodinicotinic acid to inhibit activity of poly(ADP-ribose) polymerase in said subject to thereby inhibit said effects. Also provided is a method of inhibiting occurrence of mutations and of cancers derived from mutations, which method comprises administration to a subject of a composition comprising a sufficient amount of 6,6'-dithiodinicotinic acid.

REFERENCES:
patent: 3698866 (1972-10-01), Grassetti
patent: 4152439 (1979-05-01), Grassetti
patent: 4378364 (1983-03-01), Grassetti
patent: 5608093 (1997-03-01), Stache et al.
Davis et al., In situ staining for PARP activity using and NAD analog,J.Histochem>Cytochem(1998),p46(11).
Guo et al, Inhibition of PARP rescues human T lym . . . , Toxicol. Appl. Pharmacol. p152(2), 1998.
Ariumi et al., In cico phosphorylation of PARP is ind . . . , FEBs lett. p436(2), 1998.
Ahmad et al., Hepatic-mediated elev . . . Biochem Pharmacol(england), p1697-701, May 1986.
Grassetti D.R.,Modification of external sulfhydryl . . . , Biochem Pharmacol(US), p1836-8, May 1970.

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