Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-10-16
1992-12-15
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514826, 546137, A61K 3144, C07D41300
Patent
active
051717441
ABSTRACT:
Compounds having the formula: ##STR1## wherein X is either (a) a phenyl group optionally substituted by 1 or 2 substituents each independently selected from halo, CF.sub.3, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy and hydroxy, or (b) a thienyl group; and Y is an imidazolyl, pyrazolyl, triazolyl or tetrazolyl group optionally substituted by 1 or 2 substituents each independently selected from halo, CF.sub.3, C.sub.1 -C.sub.4 alkoxy, hydroxy and amino; and pharmaceutically acceptable salts thereof, are antimuscarinic bronchodilators useful in the treatment of chronic obstructive airways disease and asthma.
REFERENCES:
patent: 3714357 (1973-01-01), Gueremy
patent: 4843074 (1298-06-01), Rzeszotarski et al.
patent: 4988691 (1991-01-01), Benelli et al.
Larsson, et al. "Hydrogen bond . . . ", Acta Pharm. Suecica 11, 304-308, 1974.
Cross Peter E.
Stobie Alan
Cintins Marianne M.
Fuller Jr. Grover F.
Ginsburg Paul H.
Kilby Scalzo Catherine S.
Pfizer Inc.
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