Antimicrobially effective derivatives of phenol and methods for

Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing

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568744, C07C 3914

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045323674

ABSTRACT:
A method is provided for the production of antimicrobially effective phenol derivatives according to general Formula I in which R.sub.1 is bromine or chlorine, R.sub.2 is methyl or ethyl, R.sub.3 is hydrogen or sodium, potassium, ammonium or by alkyl with up to 10 C-atoms substituted ammonium, magnesium, calcium, barium, aluminum, tin, bismuth, copper, zinc, R.sub.4 and R.sub.5 are independently hydrogen, alkyl or alkoxy with up to 5 C-atoms, bromine or chlorine. The compounds are obtained by benzylation of 6-halogen- or 4-halogen-2-alkylphenol, halogenation of 2-alkyl-4-benzylphenol or -6-benzylphenol, or by alkylation of 6-halogen-4-benzylphenol or of 4-halogen-6-benzylphenol and if necessary through reaction of the product with hydroxide, alcoholate, carbonate or hydrogen carbonate of the above-mentioned metals. Water or lipid soluble effective substances are obtained which display a broad antimicrobial activity spectrum.

REFERENCES:
Schroetter et al., "Chemical Abstracts", vol. 91, p. 211008a, (1979).
Proffit et al., "Chemical Abstracts", vol. 74, (1971), p. 87603y.
Teubner et al., "Chemical Abstracts", vol. 98, (1983), p. 215314.
Kramer et al., "Chemical Abstracts", vol. 88, (1978), p. 22356g.
Siegfried, "Chemical Abstracts", vol. 90, (1979), p. 121193g.

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