Antimicrobially active peptide

Details Antimicrobially active peptide Antimicrobially active peptide

2008-03-25

2008-03-25

Zeman, Robert A. (Department: 1645)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S326000, C536S023400

Reexamination Certificate

active

10735481

ABSTRACT:
An antimicrobially active peptide comprises the DCD protein or a fragment of DCD, preferably derived from the C-terminal region.

REFERENCES:
patent: 5834192 (1998-11-01), Akerblom et al.
patent: 6008195 (1999-12-01), Selsted
patent: 6420116 (2002-07-01), Olsen et al.
Schittek et al (Dermcidin: a novel human antibiotic peptide secreted by sweat glands, Nature Immunology, 2001; 2(12): 1133-1137).
Thomas E. Creighton, in his book, “Proteins: Structures and Molecular Properties”, 1984: 314-315.
Thomas E. Creighton, in his book “Protein Structure: A Practical Approach”, 1989: 184-186.
Nosoh, Y. et al “Protein Stability and Stabilization through Protein Engineering”, 1991(chapter 7, p. 197).
UniProtKB/Swiss-Prot entry P81605 http://ca.expasy.org/uniprot/P81605 pp. 1-4.
Cunningham et al, Identification of a survival-promoting peptide in medium conditioned by oxidatively stressed cell lines of nervous system origin, The journal of neuroscience, 1998; 18(18): 7047-60.
Bowie et al (Science, 1990, 257: 1306-1310).
Cunningham et al. (2000) “Calreticulin binding and other biological activities of survival peptide Y-P30 including effects of systemic treatment of rats,” Experimental Neurology 163:457-468.
Hipfel et al. (2000) “Specifically regulated genes in malignant melanoma tissues identified by subtractive hybridization,” British Journal of Cancer 82(6):1149-1157.

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