Antimicrobial surgical implants

Details Antimicrobial surgical implants Antimicrobial surgical implants

1984-04-24

1986-10-07

Apley, Richard J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

623 66, 623 16, 128 92R, 128 92C, 424132, 424 26, 4332001, A61F 202, A61F 228

Patent

active

046157050

ABSTRACT:
Surgical implants, especially endoprosthetic orthopaedic implants and sutures, are rendered antimicrobial by the presence of a bioerodible metallic silver component, especially a surface coating, which provides in vivo a sustained release of silver ions in a concentration sufficient to provide a localized antimicrobial effect but insufficient to cause significant damage to connective tissue. Latently bioerodible silver components of an implant can be activated by, for example, abrasion, heating to above about 180.degree. C. or, especially, contact with hydrogen peroxide.

REFERENCES:
patent: 2040806 (1936-05-01), Feigl
patent: 2521713 (1950-09-01), Goetz
patent: 3590486 (1971-07-01), Brenner
patent: 4027393 (1977-06-01), Ellis et al.
patent: 4252525 (1981-02-01), Child
patent: 4263681 (1981-04-01), Notton
patent: 4291125 (1981-09-01), Greatbatch
"Hackh's Chemical Dictionary", Grant, pp. 485 & 612, McGraw-Hill, 1972.
"Disinfection, Sterilization and Preservation", Block, p. 403, Lea & Febiger, 1977.

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