Antimicrobial quinolone derivatives and use of the same to...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S376000, C546S112000, C546S183000, C548S229000

Reexamination Certificate

active

06869965

ABSTRACT:
Substituted quinolone derivatives in which an oxazolidinone, isoxazolinone, or isoxazoline is covalently bonded to a quinolone, methods of using the quinolone derivatives, and pharmaceutical compositions containing the quinolone derivatives are disclosed. Methods of synthesizing these substituted quinolone derivatives are also disclosed, and in particular a method of manufacturing a 7-(2-oxo-1,3-oxazolidin-3-yl)aryl-3-quinolinecarboxylic acid by condensing a 4-(2-oxo-1,3-oxazolidin-5-yl)aryl boronic acid with a 7-halo-quinolone derivative. The quinolone derivatives possess antibacterial activity, and are effective against a number of human and veterinary pathogens in the treatment of bacterial diseases.

REFERENCES:
patent: 3669965 (1972-06-01), White
patent: 3769295 (1973-10-01), Hoyle et al.
patent: 4065463 (1977-12-01), Beck et al.
patent: 4283403 (1981-08-01), Davenport
patent: 4382892 (1983-05-01), Hayakawa et al.
patent: 4563459 (1986-01-01), Grohe et al.
patent: 4620007 (1986-10-01), Grohe et al.
patent: 4705799 (1987-11-01), Gregory
patent: 4801600 (1989-01-01), Wang et al.
patent: 4921869 (1990-05-01), Wang et al.
patent: 4948801 (1990-08-01), Carlson et al.
patent: 4977173 (1990-12-01), Brittelli et al.
patent: 4985557 (1991-01-01), Hayakawa et al.
patent: 5053407 (1991-10-01), Hayakawa et al.
patent: 5130316 (1992-07-01), Carlson et al.
patent: 5142046 (1992-08-01), Hayakawa et al.
patent: 5164510 (1992-11-01), Brickner
patent: 5254577 (1993-10-01), Carlson et al.
patent: 5523403 (1996-06-01), Barbachyn
patent: 5654435 (1997-08-01), Barbachyn et al.
patent: 5861413 (1999-01-01), Häbich et al.
patent: 6124334 (2000-09-01), Hutchinson
patent: 27 55 061 (1978-06-01), None
patent: 31 42 854 (1983-05-01), None
patent: 32 48 505 (1984-07-01), None
patent: 32 48 507 (1984-07-01), None
patent: 196 01 265 (1997-07-01), None
patent: 0 047 005 (1982-03-01), None
patent: 0 206 283 (1986-12-01), None
patent: 0 390 215 (1990-10-01), None
patent: 0 693 491 (1996-01-01), None
patent: 0 694 543 (1996-01-01), None
patent: 0 694 544 (1996-01-01), None
patent: 0 697 412 (1996-02-01), None
patent: 2 077 490 (1995-11-01), None
patent: 57088182 (1982-06-01), None
patent: 58072589 (1983-04-01), None
patent: 2-69478 (1990-03-01), None
patent: WO 9309103 (1993-05-01), None
patent: WO 9413649 (1994-06-01), None
patent: WO 9807708 (1998-02-01), None
patent: WO 9941244 (1999-08-01), None
patent: WO 0010566 (2000-03-01), None
Gregory et al., “Antibacterials. Synthesis and Structure-Activity Studies of 3-Aryl-2-oxooxazolidines. 1. The “B” Group,”J. Med. Chem., 32:1673-1681 (1989).
Hayakawa et al., “Synthesis and Antibacterial Activities of Substituted 7-Oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic Acids,”Chem. Pharm. Bull., 32:4907-4913 (1984).
Kiely et al. “Synthesis of 7-(Alkenyl, Cycloalkenyl, and 1,2, 3,6-Tetrahydro-4-pyridinyl)quinilones,”J. Heterocyclic Chem., 28:1581-1585 (1991).
Mahmood et al., “Iron Lewis Acid Catalyzed Reactions of Aromatic Aldehydes with Ethyl Diazoacetate: Unprecedented Formation of 3-Hydroxy-2-arylacrylic Acid Ethyl Esters by a Unique 1,2-Aryl Shift,”J. Org. Chem., 63:3333-3336 (1998).
Newman, Paul, “Optical Remixture Procedures for Chemical Compounds, vol. 1; Amines and Related Compounds,” Optical Remixture Information Center, Manhatten College, Riverdale, N.Y., 10471, 1978.
International Search Report dated Sep. 20, 2000.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antimicrobial quinolone derivatives and use of the same to... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antimicrobial quinolone derivatives and use of the same to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antimicrobial quinolone derivatives and use of the same to... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3373618

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.