Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-03-22
2005-03-22
Shameem, Golam M M (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S376000, C546S112000, C546S183000, C548S229000
Reexamination Certificate
active
06869965
ABSTRACT:
Substituted quinolone derivatives in which an oxazolidinone, isoxazolinone, or isoxazoline is covalently bonded to a quinolone, methods of using the quinolone derivatives, and pharmaceutical compositions containing the quinolone derivatives are disclosed. Methods of synthesizing these substituted quinolone derivatives are also disclosed, and in particular a method of manufacturing a 7-(2-oxo-1,3-oxazolidin-3-yl)aryl-3-quinolinecarboxylic acid by condensing a 4-(2-oxo-1,3-oxazolidin-5-yl)aryl boronic acid with a 7-halo-quinolone derivative. The quinolone derivatives possess antibacterial activity, and are effective against a number of human and veterinary pathogens in the treatment of bacterial diseases.
REFERENCES:
patent: 3669965 (1972-06-01), White
patent: 3769295 (1973-10-01), Hoyle et al.
patent: 4065463 (1977-12-01), Beck et al.
patent: 4283403 (1981-08-01), Davenport
patent: 4382892 (1983-05-01), Hayakawa et al.
patent: 4563459 (1986-01-01), Grohe et al.
patent: 4620007 (1986-10-01), Grohe et al.
patent: 4705799 (1987-11-01), Gregory
patent: 4801600 (1989-01-01), Wang et al.
patent: 4921869 (1990-05-01), Wang et al.
patent: 4948801 (1990-08-01), Carlson et al.
patent: 4977173 (1990-12-01), Brittelli et al.
patent: 4985557 (1991-01-01), Hayakawa et al.
patent: 5053407 (1991-10-01), Hayakawa et al.
patent: 5130316 (1992-07-01), Carlson et al.
patent: 5142046 (1992-08-01), Hayakawa et al.
patent: 5164510 (1992-11-01), Brickner
patent: 5254577 (1993-10-01), Carlson et al.
patent: 5523403 (1996-06-01), Barbachyn
patent: 5654435 (1997-08-01), Barbachyn et al.
patent: 5861413 (1999-01-01), Häbich et al.
patent: 6124334 (2000-09-01), Hutchinson
patent: 27 55 061 (1978-06-01), None
patent: 31 42 854 (1983-05-01), None
patent: 32 48 505 (1984-07-01), None
patent: 32 48 507 (1984-07-01), None
patent: 196 01 265 (1997-07-01), None
patent: 0 047 005 (1982-03-01), None
patent: 0 206 283 (1986-12-01), None
patent: 0 390 215 (1990-10-01), None
patent: 0 693 491 (1996-01-01), None
patent: 0 694 543 (1996-01-01), None
patent: 0 694 544 (1996-01-01), None
patent: 0 697 412 (1996-02-01), None
patent: 2 077 490 (1995-11-01), None
patent: 57088182 (1982-06-01), None
patent: 58072589 (1983-04-01), None
patent: 2-69478 (1990-03-01), None
patent: WO 9309103 (1993-05-01), None
patent: WO 9413649 (1994-06-01), None
patent: WO 9807708 (1998-02-01), None
patent: WO 9941244 (1999-08-01), None
patent: WO 0010566 (2000-03-01), None
Gregory et al., “Antibacterials. Synthesis and Structure-Activity Studies of 3-Aryl-2-oxooxazolidines. 1. The “B” Group,”J. Med. Chem., 32:1673-1681 (1989).
Hayakawa et al., “Synthesis and Antibacterial Activities of Substituted 7-Oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic Acids,”Chem. Pharm. Bull., 32:4907-4913 (1984).
Kiely et al. “Synthesis of 7-(Alkenyl, Cycloalkenyl, and 1,2, 3,6-Tetrahydro-4-pyridinyl)quinilones,”J. Heterocyclic Chem., 28:1581-1585 (1991).
Mahmood et al., “Iron Lewis Acid Catalyzed Reactions of Aromatic Aldehydes with Ethyl Diazoacetate: Unprecedented Formation of 3-Hydroxy-2-arylacrylic Acid Ethyl Esters by a Unique 1,2-Aryl Shift,”J. Org. Chem., 63:3333-3336 (1998).
Newman, Paul, “Optical Remixture Procedures for Chemical Compounds, vol. 1; Amines and Related Compounds,” Optical Remixture Information Center, Manhatten College, Riverdale, N.Y., 10471, 1978.
International Search Report dated Sep. 20, 2000.
Barbachyn Michael R.
Gage James R.
Gordeev Mikhail F.
Patel Dinesh V.
Pharmacia & Upjohn Company
Pharmacia & Upjohn Company
Shameem Golam M M
Wootton Thomas A.
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