Antimicrobial pyridthiones

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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546296, 546114, C07D21304, A61K 3144

Patent

active

042462665

ABSTRACT:
Antimicrobial compositions comprising as active ingredient at least one compound of the general formula ##STR1## (wherein R.sup.1 and R.sup.5, which may be the same or different each represent a hydrogen or halogen atom and R.sup.2, R.sup.3 and R.sup.4 which may be the same or different, each represent a hydrogen atom or a lower alkyl group) in association with an antimicrobial carrier, excipient or diluent. The compounds of formula I may be prepared by reacting a corresponding dihydrothiazolo 8-oxide compound with a base. Certain of the compounds of formula I are novel and may also be prepared by pyrolytic decarboxylation of a corresponding carboxyl substituted thiazolo-8-oxide compound.

REFERENCES:
Undheim et al., Acta Chemica Scandinavica, vol. 26, No. 6, pp. 2385-2400, (1972).
Hackh's Chemical Dictionary, McGraw-Hill Pub., Fourth Edition, p. 75, (1969).

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