Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1987-10-06
1992-06-30
Draper, Garnette D.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
530350, 530380, 514 12, 514 21, 435218, 424 9464, C12N 950, C07K 1500, A61K 3754
Patent
active
051262576
ABSTRACT:
The present invention provides a composition of matter useful as an antimicrobial agent. This composition of matter comprises an extract derived from human polymorphonuclear leukocytes, said extract including a polypeptide having an apparent molecular weight of about 13,000 daltons, a polypeptide having an apparent molecular weight of about 29,000 daltons and a polypeptide having an apparent molecular weight of about 54,000 daltons. The extract also has oxygen-independent, antimicrobial activity for bacteria and fungi at a pH from about 5.0 to about 8.0 and at calcium ion concentrations up to about 10 mM, bactericidal activity at sodium chloride concentrations up to about 0.3M, and fungicidal activity at sodium chloride concentrations up to about 0.15M. Methods for preparing this composition of matter are also provided. Further provided are purified polypeptides useful as antimicrobial agents, and methods for producing these polypeptides.
REFERENCES:
patent: 4343798 (1982-08-01), Fawzi
Chem. Abstract 81:102757s; Olsson et al. (1974) Blood 44, 235-246.
Chem. Abstract 84:39224k; Odeberg et al. (1975) J. Clin. Invest. 56, 1118-1124.
Heck et al., (1985) Anal. Biochem. 149, 153-162.
Gabay Joelle E.
Nathan Carl F.
Baker R. Keith
Cornell Research Foundation
Draper Garnette D.
Rockefeller University
White John P.
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