Antimicrobial proteins, compositions containing same and uses th

Details Antimicrobial proteins, compositions containing same and uses th Antimicrobial proteins, compositions containing same and uses th

1992-02-11

1994-08-16

Low, Christopher S. F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530350, 530380, 530386, 930 10, 930190, 930290, A61K 3702

Patent

active

053387244

ABSTRACT:
The present invention provides a composition of matter useful as an antimicrobial agent. This composition of matter comprises at least two polypeptides selected from the group consisting of human polymorphonuclear leukocyte, polypeptides having on apparent molecular weights of about 3,500 daltons, about 13,000 daltons, about 18,000 daltons, about 29,000 daltons, and about 54,000 daltons. The composition of matter has respiratory burst-independent, antimicrobial activity for bacteria and fungi at a pH from about 5.0 to about 8.0 and at calcium ion concentrations up to about 10 mM, bactericidal activity at sodium chloride concentrations up to about 0.3M, and fungicidal activity at sodium chloride concentrations up to about 0.15M. Methods for preparing this composition of matter are also provided.
Further provided are purified polypeptides useful as antimicrobial agents, and methods for producing these polypeptides.

REFERENCES:
patent: 4639435 (1987-01-01), Fujii et al.
patent: 4755383 (1988-07-01), Fujii et al.
patent: 5087569 (1992-02-01), Gabay et al.
Heck et al. 1986, Anal. Biochem. 158, 217-227.
Starkey et al. 1976, Biochem. J. 155, 255-263.
Ganz, T., et al.., J. Clin. Invest. vol. 76, pp. 1427-1435 (1985).
Heck, L. W., et al., Anal. Biochem. vol. 149, pp. 153-162 (1985).
Odeberg, H. and Olsson, I., J. Clin. Invest. vol. 56, pp. 1118-1124, (1974).
Olsson, I. and Venge, P., Blood vol. 44, pp. 235-246 (1974).
Salvesen, G., et al., Biochemistry vol. 26, pp. 2289-2293, (1987).
Selsted, M. E., et al., J. Clin. Invest. vol. 76, pp. 1436-1439 (1985).
Selsted, M. E., et al., J. Biol. Chem. vol. 8, pp. 4579-4584 (1985).
Selsted, M. E., et al., Infect. & Immun., vol. 45 (1) pp. 150-154 (1984).
Shafer, W. M., et al., Infect. & Immun., vol. 45 (1), pp. 29-35 (1984).

Affiliated with

Also associated with

Rating

Antimicrobial proteins, compositions containing same and uses th does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antimicrobial proteins, compositions containing same and uses th, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antimicrobial proteins, compositions containing same and uses th will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-951906