Antimicrobial proteins, compositions containing same and uses th

Details Antimicrobial proteins, compositions containing same and uses th Antimicrobial proteins, compositions containing same and uses th

1987-11-25

1992-02-11

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

530350, 530380, 514 12, 514 21, 435218, C12N 950, C07K 1500, A61K 3754

Patent

active

050875698

ABSTRACT:
The present invention provides a composition of matter useful as an antimicrobial agent. This composition of matter comprises at least two polypeptides selected from the group consisting of human polymorphonuclear leukocyte, polypeptides having on apparent molecular weights of about 3,500 daltons, about 13,000 daltons, about 18,000 daltons, about 29,000 daltons, and about 54,000 daltons. The composition of matter has respiratory burst-independent, antimicrobial activity for bacteria and fungi at a pH from about 5.0 to about 8.0 and at calcium ion concentrations up to about 10 mM, bactericidal activity at sodium chloride concentrations up to about 0.3M, and fungicidal activity at sodium chloride concentrations up to about 0.15M. Methods for preparing this composition of matter are also provided. Further provided are purified polypeptides useful as antimicrobial agents, and methods for producing these polypeptides.

REFERENCES:
Chem. Abstract 81:102757s; Olsson et al. (1974), Blood 44, 235-246.
Chem. Abstract 84:39224k; Odeberg et al. (1975), J. Clin. Invest. 56, 1118-1124.
Heck et al. (1985), Anal. Biochem. 149, 153-162.
Salvesen et al. (1987), Biochemistry 26, 2289-2293.

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