Antimicrobial polypeptides and methods of use

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Oxidoreductases

Reexamination Certificate

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C530S350000

Reexamination Certificate

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07067125

ABSTRACT:
Antimicrobial compounds and compositions and uses thereof, including the treatment and prevention of bacterial infections are described. The compounds and compositions include lantibiotic polypeptides and the nucleic acid sequences encoding the polypeptides. The compounds and compositions are useful as antimicrobials in antibiotic pharmaceutical preparation and as an antimicrobial or antiseptic dentifrice.

REFERENCES:
patent: 3031446 (1962-04-01), Zimmer et al.
patent: 3968233 (1976-07-01), Garzia
patent: 4474801 (1984-10-01), Garzia
patent: 5239088 (1993-08-01), Hoffman et al.
patent: 5352450 (1994-10-01), Koga
patent: 5401857 (1995-03-01), Grey et al.
patent: 5650320 (1997-07-01), Caufield
patent: 5843709 (1998-12-01), Entian et al.
patent: 0543195 (1993-05-01), None
patent: 9640865 (1996-12-01), None
patent: 9817685 (1998-04-01), None
Gutowski-Eckel et al.Applied and Environmental Microbiology, vol. 60, pp. 1-11, 1994.
European Search Report for European Patent Application 98928967.3-2106-US9812003, 2001.
EMBL database entry AAP91366, 1992.
Gutierrez, et al., “Insertional Mutagenesis and Recovery of Interrupted Genes of Streptococcus mutans by Using Transposon Tn917: Preliminary Characterization of Mutants Displaying Acid Sensitivity and Nutritional Requirements”, Journal of Bacteriology, vol. 178, No. 14, pp. 4166-4175, Jul. 1997.
Mota-Meira, et al., “Purification and Structure of Mutacin B-Ny266: A New Lantibiotic Produced by Streptococcus Mutans”, FEBS Letters, 410, pp. 275-279, Feb. 1997.
Hillman, et al., “Genetic and Biochemical Analysis of Mutacin 1140, A Lantibiotic from Streptococcus Mutans”, Infection and Immunity, vol. 66, No. 6, pp. 2743-2749, Nov. 1997.
Smith, et al., “Probing Structural Heterogeneity in Mutacin 1140, a Novel Lantibiotic”. Fortieth International Experimental Nuclear Magnetic Resonance Conference, Orlando, Florida, Feb. 28-Mar. 5, P034-73 (1999).
Smith, et al., “Covalent and Initial Three-Dimensional Structure of the Lantibiotic Mutacin 1140”. Southeast Magnetic Resonance Conference, Tallahassee, Florida P45-102, Fall (1999).
Mota-Meira, et al., “MICs of Mutacin B-Ny266, Nisin A, Vancomycin, and Oxacillin against Bacterial Pathogens”, Antimicrobial Agents and Chemotherapy, pp. 24-29, Jan. 2000.
Smith, et al., “Covalent Structure of Mutacin 1140 and a Novel Method for the Rapid Identification of Lantibiotics”, Eur. J. Biochem., 267, pp. 6810-6816, 2000.
Beppu, T., “Genes, enzymes and secondary metabolites in industrial microorganisms”, Journal of Industrial Microbiology, 16:360-363 (1996).
Chikandas, M., et al., “Mutacin II, a Bactericidal Lantibiotic from Streptococcus mutans”, Antimicrobial Agents and Chemotherapy, 39(12):2656-2660 (1995).
Hillman, J., et al., “Isolation of a Streptococcus mutans Strain Producing a Novel Bacteriocin”, Infection and Immunity, 44(1):141-144 (1984).
Novák, J. et al., “Isolation and Biochemical Characterization of a Novel Lantibiotic Mutacin from Streptococcus mutans”, Journal of Bacteriology, 176(14):4316-4320 (1994).
Novák, et al., “Detection of Modified Amino Acids in Lantibiotic Peptide Mutacin II by Chemical Derivatization and Electrospray Ionization—Mas s Spectroscopic Analysis”, Analytical Biochemistry, 236:358-360 (1996).
Passador, L., et al., “Functional Analysis of the Pseudomonas aeruginosa Autoinducer PAI”, Journal of Bacteriology, 178(20):5995-6000 (1996).
Schaefer, Amy, et al., “Quorum Sensing in Vibrio fischeri: Probing Autoinducer-LuxR Interactions with Autoinducer Analogs”, Journal of Bacteriology, 178(10):2897-2901 (1996).

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