Antimicrobial peptides and methods of use thereof

Details Antimicrobial peptides and methods of use thereof Antimicrobial peptides and methods of use thereof

1999-03-01

2000-08-22

Carlson, Karen Cochrane

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530350, A61K 3800, C07K 100

Patent

active

061074608

ABSTRACT:
Novel peptide analogs derived from the native sequences of CAP37 peptides 20-44 and 23-42, and their use as therapeutics against bacterial infections and diseases caused by bacterial infection. The peptide analog includes a serine or threonine substitution at one of the two cysteine residues at positions 26 and 42. Substitutions of the native peptide are also contemplated.

REFERENCES:
patent: 4652639 (1987-03-01), Stabinsky
patent: 5087569 (1992-02-01), Gabay et al.
patent: 5126257 (1992-06-01), Gabay et al.
patent: 5171739 (1992-12-01), Scott
patent: 5234912 (1993-08-01), Marra et al.
patent: 5308834 (1994-05-01), Scott et al.
patent: 5334584 (1994-08-01), Scott et al.
patent: 5338724 (1994-08-01), Gabay et al.
patent: 5447914 (1995-09-01), Travis et al.
patent: 5458874 (1995-10-01), Pereira et al.
patent: 5484885 (1996-01-01), Pereira et al.
patent: 5607916 (1997-03-01), Pereira et al.
patent: 5627262 (1997-05-01), Pereira et al.
patent: 5650392 (1997-07-01), Pereira et al.
patent: 5652332 (1997-07-01), Little, II
patent: 5688767 (1997-11-01), Hancock et al.
patent: 5877151 (1999-03-01), Pereira
Ziegler et al., "Treatment of Gram-Negative Bacteremia and Shcok with Human Antiserum to A Mutant Escherichia coli", The New England Journal of Medicine, vol. 307, No. 20, Nov. 11, 1982.
Brackett et al., "Evaluation of Cardiac Output, Total Peripheral Vascular Resistance, and Plasma Concentrating of Vasopressin in the Conscious, Unrestrained Rat During Endotoxemia", Circulatory Shock, 17:273-284, 1985.
Baumgartner et al., "Prevention of Gram-Negative Shock and Death In Surgical Patients By Antibody to Endotoxin Core Glycolipid", The Lancet, Jul. 13, 1985, pp. 59-63.
Fisher et al., "Initial Evaluation of Human Monoclonal Anti-Liquid A Antibody (HA-1A) in Patients with Sepsis Syndrome", Critical Care Medicine, vol. 18, No. 12, 1990, 1311-1315.
Ziegler et al., "Treatment of Gram-Negative Baceteremia and Septic Shock With HA-1A Human Monoclonal Antibody Against Endotoxin", The New England Journal of Medicine, vol. 324, No. 7, Feb. 14, 1991, pp. 429-439.
Greenman et al., "A Controlled Clinical Trial of E65 Murine Monoclonal IgM Antibody to Endotoxin in the Treatment of Gram-Negative Sepsis", JAMA, vol. 266, No. 8, Aug. 28, 1991, pp. 1097-1102 and 1125-1126.
J. Johnston, "Molecular Science Sets Its Sights on Septic Shock", The Journal of NIH Research, vol. 3, Oct. 1991, pp. 61-65.
"Anti-Endotoxin Monoclonal Antibodies", various editorials, The New England Journal of Medicine, vol. 327, No. 12, Sep. 17, 1992, pp. 889-890
C. Welbourn and Y. Young, "Endotoxin, Septic Shock and Acute Lung Injury: Neutrophils, Macrophages and Inflammatory Mediators", Br. J. Surg., vol. 79, Oct. 1992, pp. 998-1003.
Dialog (R) file 155 Accession No. 93226936, Offenstadt, G. et al., Jan. 1, 1993. "Therapeutic Perspective of Severe Infectious States", Rev. Prat (France), vol. 43, No. 1, Abstract only.
W. Hoffman, and C. Natanson, "Endotoxin in Septic Shock", Anesth Analg, 1993:77:613-24.
W. Ammons and A. Kung, "Recombinant Amino Terminal Fragment of Bactericidal/Permeability-Increasing Protein Prevents Hemodynamic Responses to Endotoxin", Circulatory Shock, 41:176-184, 1993.
Pereira et al., "Synthetic Bactericidal Peptide Based on CAP37: A 37kDa Human Neutriphil Granule-Associated Cationic Antimicrobial Protein Chemotactic for Monocytes", Proc. Natl. Acad. Sci. USA, vol. 90, pp. 4733-4737, May 1993.
Cross et al., Jul. 1993, "Choice of Bacteria in Animal Models of Sepsis", Infection and Immunity, vol. 61, No. 7, pp. 2741-2747.
S. Aldridge, "Meeting the Challenge of Sepsis", TIBTECH, vol. 11, Sep. 1993
Dialog (R), File 72, Embase No. 94208915, Rogy et al., 1994. Anti-endotoxin Therapy in Primate Bacteremia With HA-1A and BPI, Ann Surg (USA), vol. 220, No. 1, Abstract only.
Stewart et al., "Comparison of Staphylococcus aureus and Escherichia coli Infusion in Conscious Rats", Journal of Surgical Research, 56, 60-66, 1994.
J. Gabay, "Ubiquitous Natural Antibiotics" Science, vol., 264, Apr. 15, 1994, pp. 373-374.
Dialog (R), File 72, Embase No. 95085016, Hurley, J.C., 1995. "Endotoxaemia and Novel Therapies for the Treatment of Sepsis", Expert Opinion on Investigational Drugs (United Kingdom), vol. 4, No. 3, Abstract only.

Affiliated with

Also associated with

Rating

Antimicrobial peptides and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antimicrobial peptides and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antimicrobial peptides and methods of use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-582470