Antimicrobial peptides and methods of identifying the same

Details Antimicrobial peptides and methods of identifying the same Antimicrobial peptides and methods of identifying the same

2011-07-26

2011-07-26

Audet, Maury (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

C530S326000, C514S001100, C424S001690

Reexamination Certificate

active

07985836

ABSTRACT:
Antimicrobial peptides and methods of identifying the same are provided.

REFERENCES:
patent: 4683195 (1987-07-01), Mullis
patent: 4965188 (1990-10-01), Mullis
patent: 2006/0223755 (2006-10-01), Grote
patent: 2004058798 (2004-07-01), None
patent: WO 2004058798 (2004-07-01), None
patent: 2004/067563 (2004-08-01), None
patent: 2007/148078 (2007-12-01), None
Papo et al.; 2004; “Effect of drastic sequence alteration and d-amino acid incorporation on the membrane binding behavior of lytic peptides,” Biochemistry; 43:6393-6403.
Piotto et al.; 1992; “Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions,” J. Biomol. NMR; 2:661-665.
Porcelli et al.; Oct. 29, 2004; “Structure and orientation of parsdaxin determined by NMR experiments in model membranes,” J. Biol. Chem.; 279:45815-45823.
Powers et al.; 2005; “Solution structure and interaction of the antimicrobial polyphemusins with lipid membranes,” Biochemistry; 44:15504-15513.
Putsep et al.; Oct. 12, 2002; “Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study,” Lancet; 360:1144-1149.
Rance et al.; Dec. 16, 1983; “Improved spectral resolution in COSY 1H NMR spectra of proteins via double quantum filtering,” Biochem. Biophys. Res. Commun.; 117:479-485.
Rosenfeld et al.; Jan. 20, 2006 (published, papers in press, Nov. 17, 2005); “Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides,” J. Biol. Chem.; 281:1636-1643.
Rozek et al.; 2000; “The antibiotic and anticancer active aurein peptides from the Australian bell frogsLitoria aureaandLitoria raniformis,” Eur. J. Biochem.; 267:5330-5341.
Schwieters, C.D., et al., “The Xplor-NIH NMR molecular structure determination package,” J. Magnetic Resonance, 160:65-73 (2003).
Shai et al.; Mar. 29, 1996; “Diastereomers of cytolysins, a novel class of potent antibacterial peptides,” J. Biol. Chem.; 271:7305-7308.
Sigurdardottir, T. et al.; 2006, “In Siulico Identification and Biological Evaluation of Antimicrobial Peptides Based on Human Cathelicidin LL-37;” Antimicrobial Agents and Chemotherapy, vol. 50, No. 9, p. 2983-2989.
Sorenson et al.; Oct. 1, 1997; “The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils,” Blood; 90:2796-2803.
Spera et al.; 1991; “Empirical correlation between protein backbone conformation and Calpha and Cbeta 13C nuclear magentic resonance chemical shifts,” J. Am. Chem. Soc.; 113:5490-5492.
Tjabringa et al.; 2003; “The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor,” J. Immunol.; 171:6690-6696.
Wang et al.; 1996; “Conformations of human apolipoprotein E(263-286) and E(267-289) in aqueous solutions of sodium dodecyl sulfate by CD and 1H NMR,” J. Biochemistry; 35:10358-10366.
Wang et al.; 1996; “Conformation of human serum apolipoprotein A-I(166-185) in the presence of sodium dodecyl sulfate or dodecylphosphocholine by 1H-NMR and CD. Evidence for specific peptide-SDS interactions,” Biochimica et Biophysica Acta; 1301:174-184.
Wang et al.; 1997; “The helix-hinge-helix structural motif in human apolipoprotein A-I determined by NMR spectrocopy,” J. Biochemistry; 36:13657-13666.
Wang et al.; Dec. 22, 2000; “A novel membrane anchor function for the N-terminal amphipathic sequence of the signal-transducing protein IlAglucose of theEscherichia coliphosphotransferase system,” J. Biol. Chem.; 275:39811-39814.
Wang et al.; Jun. 2, 2000; “A common interface on histidine-containing phospohcarrier protein for interaction with its partner proteins,” J. Biol. Chem.; 275:16401-16403.
Wang, G.; 2002; “How the lipid-free structure of the N-terminal truncated human apoA-I converts to the lipid-bound form: new insights from NMR and X-ray structural comparison,” FEBS Lett.; 529:157-161.
Wang et al.; 2003; “Solution structure of the N-terminal amphitropic domain ofEscherichia coliglucose-specific enzyme IIA in membrane-mimetic micelles,” Protein Sci.; 12:1087-1096 and 1 cover sheet.
Wang, G., et al., “Short-chain diacyl phosphatidylglycerols: which one to choose for the NMR structural determination of a membrane-associated peptide fromEscherichia coli?” Spectroscopy, 18:257-264, (2004).
Wang et al.; 2004; “APD: the antimicrobial peptide database,” Nucleic Acids Res.; 32:D590-D592.
Wang et al.; Feb. 18, 2005; “Correlation of three-dimensional structures with the antibacterial activity of a group of peptides designed based on a nontoxic bacterial membrane anchor,” J. Biol. Chem.; 280:5803-5811.
Wang, G., “Structural biology of antimicrobial peptides by NMR spectroscopy,” Current Organic Chemistry, 10 (5):569-581, (2006).
Wishart et al.; 1991; “Relationship between nuclear magnetic resonance chemical shift and protein secondary structure,” J. Mol. Biol.; 222:311-333.
Yu et al.; 2002; “Solution structure of a cathelicidin-derived antimicrobial peptide, CRAMP as determined by NMR spectroscopy,” J. Pept. Res.; 60:1-9.
Zanetti, M., “Cathelicidins, multifunctional peptides of the innate immunity,” J. Leukoc. Biol., 75:39-48, (2004).
Zasloff, M.; 2002; “Antimicrobial peptides of multicellular organisms,” Nature; 415:389-395.
Zhang et al.; 2003; “Binding of peptides with basic and aromatic residues to bilayer membranes,” J. Biol. Chem.; 278:21459-21466.
Agerberth et al.; Nov. 1, 2000; “The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations,” Blood; 96(9):3086-3093.
Allen et al.; 2003; “Structure of gramicidin A in a lipid bilayer environment determined using molecular dynamics simulations and solid-state NMR data,” J. Am. Chem. Soc.; 125:9868-9877.
Bax et al.; 1985; “MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy,” J. Magn. Reson.; 65:355-360.
Bechinger, B., “Detergent-like properties of magainin antibiotic peptides: A 31P solid-state NMR spectroscopy study,” Biochimica et Biophysica Acta, 1712:101-108, (2005).
Bowdish et al.; 2004; “The human cationic peptide LL-37 induces activation of the extracellular signal-regulated kinase and p38 kinase pathways in primary human monocytes,” J. Immunol.; 172:3758-3765.
Braff et al.; 2005; “Structure-function relationships among human cathelicidin peptides: dissociation of antimicrobial properties from host immunostimulatory activities,” J. Immunol.; 174:4271-4278.
Brahmachary et al.; 2004; “ANTIMIC: a database of antimicrobial sequences,” Nucleic Acids Res.; 32:D586-589.
Burley et al.; 1985; “Aromatic-aromatic interaction: a mechanism of protein structure stabilization,” Science; 229:23-28 and one sheet of abstract.
Chen et al.; Apr. 1, 2005; “Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificicty/therapeutic index,” J. Biol. Chem.; 280:12316-12329.
Clore et al.; 1998; “Determining the structures of large proteins and protein complexes by NMR,” Trends Biotechnol. 16:22-34.
Cornilescu et al.; 1999; “Protein backbone angle restraints from searching a database for chemical shift and sequence homology,” J. Biomol. NMR; 13:289-302.
Delaglio et al.; 1995; “NMRPipe: a mutlidimensional spectral processing system based on UNIX pipes,” J. Biomol. NMR; 6:277-293.
Di Nardo et al.; 2003; “Cutting edge: mast cell antimicrobial activity is mediated by expression of cathelicidin antimicrobial peptide,” J. Immunol.; 170:2274-2278.
Dorschner et.al.; 2001; &#

Affiliated with

Also associated with

Rating

Antimicrobial peptides and methods of identifying the same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antimicrobial peptides and methods of identifying the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antimicrobial peptides and methods of identifying the same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2663316