Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1997-09-18
1999-08-31
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530325, 530326, 530327, 514 12, 514 13, 514 14, C07K 700
Patent
active
059455071
ABSTRACT:
The invention is directed to antimicrobial peptides which correspond in sequence to selective amino acid sequences in viral transmembrane proteins. In particular, the proteins are derived from lentiviruses, primarily HIV and SIV. The peptides comprise arginine-rich sequences, which, when modeled for secondary structure, display a high amphipathicity and hydrophobic moment. They are highly inhibitory to microorganisms, while being significantly less active in regard to mammalian cells. As a result, the peptides of the invention may be defined as selective antimicrobial agents. The invention is also directed to antimicrobial peptides which are structural and functional analogs and homologs of the peptides and which exhibit selective inhibitory activity towards microorganisms. The invention is also directed to pharmaceutical compositions comprising the antimicrobial peptides of the invention and to methods for their use in inhibiting microbial growth and treatment of microbial infections.
REFERENCES:
patent: 5714577 (1998-02-01), Montelaro et al.
HCAPLUS AN 1995: 654063, Koenig et al., Mol. Membr. Biol., 12(1), 77-82. (abstract).
HCAPLUS AN 1994: 678717, Chernomordik et al., J. Virol., 68 (11), 7115-23. (abstract).
HCAPLUS AN 1994: 242315, Miller et al., Aids Res. Hum. Retroviruses, 9(ii), 1057-66. (abstract); 1993.
Burroughs Tencza Sarah
Mietzner Timothy A.
Montelaro Ronald C.
Delacroix-Muirheid C.
Tsang Cecilia J.
University of Pittsburgh
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