Antimicrobial peptide and use thereof

Details Antimicrobial peptide and use thereof Antimicrobial peptide and use thereof

2007-02-13

2007-02-13

Tsang, Cecilia J. (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Reexamination Certificate

active

10852136

ABSTRACT:
An object of the invention is to provide an antimicrobial peptide having an amino acid sequence which is different from a peptide existing and functioning as an antimicrobial peptide in the natural world and is not based on the conventional developmental approach for an antimicrobial peptide-containing antimicrobial agent, and a polynucleotide coding for said peptide. Another object is to provide an antimicrobial agent which contains such an antimicrobial peptide. Namely, an antimicrobial peptide represented by a general formula (1)in-line-formulae description="In-line Formulae" end="lead"?(Xa)n-S  (1)in-line-formulae description="In-line Formulae" end="tail"?wherein Xa of the formula (1) is a hydrophilic amino acid residue, n is an integer of from 1 to 6, two or more of the Xa may be the same or different from one another, S is a peptide represented by hydrophobic amino acid part-basic amino acid part-bridge part-basic amino acid part-hydrophobic amino acid part, and amino acid residue of the bridge part is selected from the group consisting of hydrophobic amino acids and neutral amino acids.

REFERENCES:
patent: 5962637 (1999-10-01), Shone et al.
Molecular Design of Peptide Antimicrobial Agent.

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