Antimicrobial fatty acid derivatives

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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424320, C08H 300, A01N 920

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active

041442563

ABSTRACT:
Acetylthio amides and esters were prepared by the free radical addition of thiolacetic acid to the terminal and nonterminal double bonds of N-substituted fatty amides and fatty esters. The free radical additions of the thiolacetic acid to the unsaturated compounds were initiated by irradiation using cobalt-60. The process using irradiation with cobalt-60 was also used to bring about the addition of bromotrichloromethane to N-substituted fatty amides and fatty esters to produce halogen-containing amides and esters. These new sulfur or halogen-containing compounds were found to have antimicrobial activity and to possess properties making them useful as antimicrobial agents.

REFERENCES:
bailey et al., JAOCS, Oct. 1976, pp. 632-633.
Mod et al., JAOCS, Nov. 1972, pp. 634-635.

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