Drug – bio-affecting and body treating compositions – Anti-perspirants or perspiration deodorants
Reexamination Certificate
2002-01-16
2004-03-23
Dodson, Shelley A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Anti-perspirants or perspiration deodorants
C424S400000, C424S401000
Reexamination Certificate
active
06709647
ABSTRACT:
TECHNICAL FIELD
The present invention relates to an antimicrobial deodorant composition, which is designed in particular for use on the human body. The composition is based on a synergistically active antimicrobial mixture of picolinic acid and a peroxyl species or equivalent source thereof.
BACKGROUND
It is well known that freshly secreted sweat is sterile and that body malodour is the result of biotransformation of the sweat by microorganisms living on the surface of the skin to produce volatile odoriferous compounds.
There are three types of material routinely used to combat body malodour: perfumes, antiperspirants and deodorants.
Perfumes typically work by simply masking body malodour.
Antiperspirants work by blocking the sweat glands, thereby reducing perspiration. However, even the best cosmetically acceptable antiperspirants rarely reduce sweat production by more than 50%.
Typical deodorants work by reducing the population of micro-organisms living on the surface of the skin, thereby reducing the extent of sweat biotransformation referred to above. Typical deodorants include ethanol and triclosan (2,4,4′-trichloro,2′-hydroxy-diphenyl ether). However, the antimicrobial benefit and subsequent malodour reduction obtained with such deodorants, particularly many hours after application, is not always excellent.
We have discovered that synergistic mixtures of picolinic acid and a peroxyl species or equivalent source thereof can achieve the target of providing an excellent antimicrobial benefit and subsequent malodour reduction.
Peroxyl species, in particular hydrogen peroxide and sources thereof, are well-known antimicrobial agents, although they have not been widely used in deodorant products for use on the human body. It is also known that the stability of such materials can be improved by the addition of small amounts of transition metal chelator. The use of dipicolinic acid for such purpose is described in several publications, for example EP 666,307 A (Procter and Gamble). Dipicolinic acid is also claimed to improve the antimicrobial effect hydrogen peroxide—see EP 845,526 A (Eka Chemicals).
Picolinic acid has been described in WO9007501 (Solvay Interox) as a stabiliser for percarboxylic acid bleaching compositions. The picolinic acid is added in minor amounts to sequester transition metals which catalyse peroxygen compound decomposition. Picolinic acid is also listed as an optional component for this purpose in EP 1,074,607 (Ausimont S.p.A.).
None of the prior art discloses or suggests the products of the present invention, nor the excellent antimicrobial and malodour reduction benefits obtainable by the use thereof.
SUMMARY OF THE INVENTION
We have found that use of a synergistic mixture of picolinic acid and a peroxyl species or equivalent source thereof gives an excellent antimicrobial effect and subsequent malodour reduction—much greater than that obtained from either of the two components individually. In addition, the addition of picolinic acid at such a level as to give said synergistic benefit enables less of the peroxyl species or equivalent source thereof to be used in the product—a significant benefit for products used on the human body.
Thus, in a first aspect of the invention, there is provided a deodorant product comprising picolinic acid and a peroxyl species or equivalent source thereof, characterised in that the molar ratio of picolinic acid to peroxyl species or equivalent source thereof is from 1:30 to 100:1.
In a second aspect of the present invention, there is provided a cosmetic method of gaining a deodorancy benefit on the human body comprising the use of picolinic acid and a peroxyl species or equivalent source thereof.
In a third aspect of the present invention, there is provided a method for the manufacture of a deodorant composition comprising the mixing of picolinic acid and a peroxyl species or equivalent source thereof with a cosmetically acceptable carrier material.
DETAILED DESCRIPTION OF THE INVENTION
The antimicrobial and deodorancy benefit derived from use of the present invention may be gained by independent application of picolinic acid and the peroxyl species or equivalent source thereof. Such application may be concurrent or consecutive, provided that the treated substrate experiences the presence of both components at the same time. When the components are applied from independent compositions, it is preferred that the product also comprises a means for, and/or instruction for, both of the compositions to be applied to the human body.
It is preferred that the picolinic acid and the peroxyl species or equivalent source thereof are applied from the same composition. A preferred product according to the invention is a single composition comprising both the picolinic acid and the peroxyl species or equivalent source thereof.
In most aspects of the present invention, the deodorant product is applied to the human body or to articles worn in close proximity thereto. Particularly effective malodour reduction is achieved via direct application to the human body. The greatest benefit is obtained on application to the most malodorous regions of the human body, in particular the underarm regions and the feet.
The cosmetic method of gaining a deodorancy benefit on the human body referred to in the second aspect of the present invention preferably uses the picolinic acid and the peroxyl species or equivalent source thereof at a molar ratio of from 1:30 to 100:1. This molar ratio, and that present in the deodorant product according to the first aspect of the invention, is more preferably from 1:20 to 50:1 and most preferably from 1:10 to 20:1.
Picolinic Acid
Picolinic acid is an essential component in the products of the invention. It may be used at a level of from 0.01% to 10%, particularly from 0.1% to 5%, and especially from 0.15% to 2.5%, by weight based on total weight of the composition of which it is a part. The picolinic acid may be used in its acid form or as its salt. Suitable salts include alkaline metal salts, alkaline earth metal salts, amine salts, and quaternary ammonium salts. When the picolinic acid is partially or totally in its salt form, the preferred amount is equivalent to the aforementioned preferred levels, on a molar basis.
Peroxyl Species or Equivalent Source Thereof
The products of the invention comprise a peroxyl species per se or a material that generates a peroxyl species in situ. A peroxyl species is one that comprises a peroxy (—O—O—) group. Examples of suitable peroxyl species include hydrogen peroxide and peracids. Examples of equivalent sources thereof are compounds that produce hydrogen peroxide on dissolution in water, such as sodium perborate monohydrate, sodium perborate tetrahydrate, sodium percarbonate and percarbamide (urea-hydrogen peroxide addition compound). Further examples are enzymatic hydrogen peroxide generating systems such as peroxidases, oxidases and other oxido-reductase enzyme systems, in conjunction with their appropriate substrates. Preferred products comprise a peracid, in particular phthalimidoperoxy hexanoic acid, or a compound that produces hydrogen peroxide on dissolution in water, rather than hydrogen peroxide itself.
Particularly preferred products comprise a compound that produces hydrogen peroxide on dissolution in water, especially products from which hydrogen peroxide is absent, prior to application.
The amount of peroxyl species or equivalent source thereof in compositions of the invention may range from 0.0001% to 5%, more preferably from 0.001 to 1.5%, most preferably from 0.005% to 0.5%, by weight based on total weight of the composition of which it is a part.
Product Forms
The products of the invention may comprise compositions taking any form. When the product comprises more than one composition, it is preferred that the compositions take the same form. Example compositions include wax-based sticks, soap-based sticks, compressed powder sticks, roll-on suspensions or solutions, emulsions, gels, creams, squeeze sprays, pump sprays, and aerosols. Each product for
Bhakoo Manmohan
Grimshaw Sally Gillian
Steele Karen Anne
Taylor David
Thompson Katherine Mary
Dodson Shelley A.
Stein Kevin J.
Unilever Home & Personal Care USA a division of Conopco, Inc.
LandOfFree
Antimicrobial deodorant compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antimicrobial deodorant compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antimicrobial deodorant compositions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3233324