Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Reexamination Certificate
2000-03-23
2001-05-01
Levy, Neil S. (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
C424S404000, C424S405000, C424S406000, C424S411000, C424S423000, C424S443000, C424S447000, C424S448000, C424S449000, C424SDIG001, C424S618000, C424S619000, C523S122000
Reexamination Certificate
active
06224898
ABSTRACT:
GOVERNMENT INTEREST
The invention described herein may be manufactured, used and/or licensed by or for the United States Government.
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates generally to antimicrobial compounds and to topical compositions and wound dressings containing antimicrobial compounds. More particularly, the present invention provides dendritic polymer-metal containing composite materials and methods of using such materials for disinfecting and/or sterilizing wounds. Most particularly, the present invention provides composite compositions of matter in which discrete nanosized inorganic materials, for example, silver, cerium, zinc, etc., are distributed on or in a dendritic polymer, and in which the size and size-distribution of the nanosized inorganic materials are determined and controlled by the dendritic polymer.
2. Description of the Related Art
Silver is an effective antimicrobial agent with low toxicity which is particularly important in the topical antibacterial treatment of burn wounds where transient bacteremia is known to frequently occur in association with burn wound manipulation. Silver sulfonamides, particularly silver sulfadiazine (AgSD) has been a standard treatment for burns for at least the past two decades, either alone or in combination with other antibiotics, cerium compounds, zinc compounds and combinations thereof It has been suggested that the basic function of the almost insoluble AgSD may be to slow the release of silver into the superficial wound environment. Silver chloride was assumed to form at the burn wound and absorption of silver was believed to be negligible. In accordance with this assumption, it has been found that serum and tissue silver levels with 10% silver nitrate used in bums produced no difference from that of 1% silver sulfadiazine cream.
However, sulfonamide-resistant organisms have been reported as a frequent consequence of the clinical use of sulfadiazine silver. It was also shown that the sulfadiazine component is not necessary for in vitro sensitivity and that the use of sulfadiazine silver can, in every case, lead to the selection of organisms that are resistant not only to sulfonamides but to antibiotics of clinical consequence. Despite major advances in burn wound management and other supportive care regimens, infection remains the leading cause of morbidity and mortality in the thermally injured patient, and a search for different treatments and new ideas is continuing. Application of silver-binding membranes has recently been suggested to further reduce the likelihood of silver toxicity to retard the movement of silver ions and minimize silver absorption at a healing wound. See Greenfield, E., McManus, A. T.,
Nurs. Clin. North Am
., 1997, 32(2), 297.
SUMMARY OF THE INVENTION
The general objective of the present invention is to provide improved antimicrobial agents which are, for example, useful for the treatment of burn wounds.
Accordingly, it is an object of the present invention to provide an antimicrobial composite composition of matter comprising inorganic materials distributed on or in a polymeric material.
It is a further object of the present invention to provide a composite antimicrobial composition of matter comprising discrete nanosized inorganic materials such as elemental silver, cerium, and zinc or compounds of the same, distributed on or in dendritic polymers.
It is still a further object of the present invention to provide a composite material in which the size and size-distribution of the distributed nanosized inorganic materials are determined and controlled by the dendritic polymer.
It is yet another object of the present invention to provide a composite antimicrobial composition of matter having improved effectiveness because the dendrimer host is soluble and able to deliver the immobilized metal by its own diffusion, while the metal remains active because of its extremely high surface area
It is still a further object of the present invention to provide an improved method of treating wounds, particularly burn wounds.
The foregoing and other objects and advantages of the present invention will hereafter become more fully apparent from the following detailed description.
REFERENCES:
patent: 4036808 (1977-07-01), Rembaum et al.
patent: 4472509 (1984-09-01), Gansow et al.
patent: 5219564 (1993-06-01), Zalipsky et al.
patent: 5366735 (1994-11-01), Henry
Roberts et al—Using Starburst Dendrimers—Bioconjugate Chem. 1990 (2) pp. 305-308.
Balogh Lajos
Hagnauer Gary L.
McManus Albert T.
Tomalia Donald A.
Biffoni U. John
Clohan, Jr. Paul S.
Levy Neil S.
The United States of America as represented by the Secretary of
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