Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
1999-08-23
2002-05-14
Fay, Zohreh (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S572000
Reexamination Certificate
active
06387947
ABSTRACT:
FIELD OF THE INVENTION
The invention relates to novel cosmetic compositions. In particular, the invention relates to cosmetic compositions having unique antimicrobial and antiirritant properties.
BACKGROUND OF THE INVENTION
Water miscible cosmetic and toiletry formulations are frequently susceptible to microbial contamination, due to their high water content and the nature of ingredients that they often contain. This is particularly true with the trend toward “natural” cosmetic ingredients, which are more likely to be susceptible to contamination than synthetic ingredients may be. The occurrence of microbial contamination in a cosmetic formulation can result in an unpleasant odor or the destabilization of an emulsion; this in turn can lead to the necessity of reformulation or recall of a commercial product.
To counteract this problem, it is often necessary to add antimicrobial chemicals, such as preservatives or biocides, to the formulation to prevent the growth of microbes that may be introduced during the manufacturing, filling or use of the product. However, such additives have recently fallen into disfavor, in large part because many preservatives are perceived as causing irritation and consumers are now demanding preservative-free products. Therefore, the market is shifting toward lower levels of conventional preservatives, and also the replacement of conventional preservatives with new molecules. Thus, there is now a strong demand for cosmetic formulations which are non-irritating and free of traditional preservatives, but which will remain stable and free of contamination in the hands of the consumer. The present invention provides such formulations.
SUMMARY OF THE INVENTION
The present invention relates to a cosmetic or pharmaceutical formulation for topical application which comprises an antimicrobial effective amount of 3-furan carboxylic acid. In a preferred embodiment, the formulation also comprises an anti-irritant effective amount of ferulic acid, or a derivative thereof. In a particularly preferred embodiment, the formulation also comprises an antimicrobial effective amount of 2-furan carboxylic acid. All such formulations are capable of being made free of preservatives, and achieve the desired effects by the use of naturally occurring materials.
The invention also relates to method for reducing the irritant effect of a cosmetic or pharmaceutical formulation comprising adding to the formulation an anti-irritant effective amount of ferulic acid or a derivative or analog thereof, as well as reducing or preventing irritation on the skin by topical application to the skin of a formulation containing ferulic acid or a derivative thereof. The invention further relates to a method for reducing or preventing inflammation which comprises applying to the skin an anti-inflammatory effective amount of 2-furan carboxylic acid, 3-furan carboxylic acid, or a combination thereof. Also encompassed is a method for inhibiting microbial growth in a cosmetic or pharmaceutical formulation which comprises adding to the formulation an antimicrobial effective amount of 3-furan carboxylic acid.
Also provided by the invention are topical cosmetic and pharmaceutical compositions useful in the treatment of inflammation in the skin comprising effective amounts of 2-furan carboxylic acid, 3-furan carboxylic acid, or a mixture thereof, as well as methods of treating inflammatory reactions in the skin comprising applying such compositions to the skin.
REFERENCES:
patent: 3320133 (1967-05-01), Suga et al.
patent: 5387605 (1995-02-01), Beilfuss et al.
patent: 5824326 (1998-10-01), Grotty et al.
patent: 582 359 (1994-02-01), None
patent: 801945 (1997-10-01), None
patent: 2 258 836 (1975-08-01), None
patent: 59 067211 (1984-04-01), None
patent: 06 256137 (1994-09-01), None
Action of Ferulic Acid and its Derivatives as Antioxidants, Kunio Yagi and Nobuko Ohishi, J. Nutr. Sci. Vitaminol., 25, 127-130, 1979.
The Multiactive Efficacy of Ferulic Acid in Cosmetics, Dr. Heinz Eggensperger, Chematic Consulting.
Hamburg, Michele Wilker, GfN GmbH, Wald Michelbach.
Antioxidant Potential of Ferulic Acid, Ernst Graf, Free Radical BViology & Medicine, vol. 13, pp. 135-148 1992.
The Multiactive Efficacy of Ferulic Acid and its Esters in Cosmetics, Dr. Heinz Eggensperger, Michele Wilker.
Vanllin as an Antimicrobial for Producing Shelf-Stable Strawberry Puree Patricia Cerrutti, Stella M. Alzamonia, and Susana L. Vidales—J. of Food Science, vol. 62, No. 3, 1997.
Chemical Abstracts, vol. 92, No. 23 published Jun. 9, 1980; abstract No. 92:198185 “Use Of Peroxide Oxidation of Furan Aldehydes . . . ” Krapivin et al.
“Study Of Antibacterial And Antiinflammatory Components Of Achillea Alpina” Journal Of Traditional Chinese Medicine, vol. 3, No. 3 published 1983, pp. 213-216 Meilan et al.
Chemical Abstracts, vol. 104, No. 11 published Mar. 17, 1986, abstract No. 104:81532 “Pharmacological Effect Of The Organic Acids Of Achillea Alpina” Li et al.
Declercq Lieve
Schnittger Steven F.
E-L Management Corp.
Fay Zohreh
Lowney, Esq. Karen A.
LandOfFree
Antimicrobial cosmetic compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antimicrobial cosmetic compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antimicrobial cosmetic compositions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2905793