Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-07-05
2011-07-05
Anderson, Rebecca L (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S241000
Reexamination Certificate
active
07973065
ABSTRACT:
The compounds disclosed herein are isoxazole derivatives that are useful as antimicrobial compounds, particularly as anti-bacterial compounds. The disclosed methods comprise incubating at least two different substrates in the presence of at least one oxygenase to provide the disclosed compounds, or to prepare and identify compounds that have antimicrobial activity.
REFERENCES:
patent: 2009/0221655 (2009-09-01), Josyula et al.
Okuda et al. J. Phys. Chem. A 2008, 112, pp. 11213-11222.
McClay, K., et al.; Toluene Monooxygenase-Catalyzed Epoxidation of Alkenes; Appl. Environ. Microbiol. 66, 2000.
Rattan, A., et al.; Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives; Emer. Infec. Dis. 4, 1998.
Surendra, S.K., et al.; Multidrug-Resistant Tuberculosis; Chest 130, 2009.
World Health Organization (WHO), 2009; Global tuberculosis control—epidemiology, strategy, financing; WHO Report 2009.
Zoller; New recombinant DNA methodology for protein engineering; Curr. Opin. Biotech. 3, 1992.
Almquist et al.; Synthesis and Biological Activity of a Ketomethylene Analogue of a Tripeptide Inhibitor of Angiotensi Converting Enzyme; J. Med. Chem. 23, 1980.
Altman, L.K.; Drug-resistant TB Rising Sharply, WHO Warns. Herald Tribune, Feb. 26, 2008.
Altschul et al.; Basic Logical Alignment Search Tool; J. Mol. Biol. 215, 1990.
August, P.R., et al.; Sequence Analysis and Functional Characterization of the Violacein Biosynthetic Pathway from Chromobacterium Violaceum; J Mol Microbiol Biotechnol 4, 2000.
Banerjee et al.; Extensively drug-resistant tuberculosis: new strains, new challenges, Expert Rev. Anti Infect Ther. 6(5), 2008.
Bao B., et al.; Bisindole alkaloids of the tosentin and hamacanthin classes from a marine sponge Spongosorities sp.; J Nat Prod 2007.
Broun et al.; Catalytic Plasticity of Fatty Acid Modification Enzymes Underlying Chemical Diversity of Plant Lipids; Science 282, 1998.
Byrne et al.; Sequence analysis of the gene cluster encoding toluene-3-monooxygenase from Pseudomonas pickettii PKO1; Gene 154, 1995.
Changsen, C., et al.; Improved Green Fhlorescent Protein Reporter Gene-Based Microplate Screening for Antituberculosis Compounds by Utilizing an Acetamidase Promoter; Antimicrob Agents Chemother 47, 2003.
Cho, S.H., et al.; Low Oxygen Recovery Assay (LORA) for High Throughput Screening of Compounds Against Non-Replicating Mycobacterium Tuberculosis; Antimicrob Agents Chemother, Apr. 2007.
Cohn, D.L., et al.; Drug-Resistant Tuberculosis: Review of the Worldwide Situation and the WHO/IUATLD Global Surveillance Program; Clin. Infect. Dis. 24, Jan. 1997.
Collins, L., et al.; Microplate Alamar Bhue Assay Versus BACTEC 460 System for High-Throughput Screening of Compounds Against Mycobacterium tuberculosis and Mycobacterium avium; Antimicrob Agents Chemother 41, May 1997.
de Lorenzo et al.; Analysis of Pseudomonas gene products using lacIq/Ptrp-lac plasmids and transposons that confer conditional phenotypes; Gene 123, 1993.
Dooley, S.W., et al.; Multi-drug resistant tuberculosis (editorial); Ann. Intern. Med 117, 1992.
Emirdag-Ozturk, S., et al.; Synthesis and antibacterial activity of egonol derivatives; Bioorg Med Chem 16, 2008.
Ensley et al.; Expression of Naphthalene Oxidation Genes inEscherichia coliResults in the Biosynthesis of Indigo; Science 222, 1983.
Feig et al.; Reactions of Non-Heme Iron(II) Centers with Dioxygen in Biology and Chemistry Chem. Rev. 94, 1994.
Franzblau, S.G., et al.; Rapid, Low-Technology MIC Determination with Clinical Mycobacterium tuberculosis Isolates by Using the Microplate Alamar Blue Assay; J. Clin. Microb. Feb. 1998.
Giese et al.; The Role of Individual Cystein Residues in the Structure and Function of the v-sis Gene Product; Science 236, 1987.
Gillespie, D.E., et al.; Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA; Appl. Environ Microbiol. 68, 2002.
Hann, M., et al.; On the Double Bond Isostere of the Peptide Bond: Preparation of an Enkephalin Analogue; J. Chem. Soc., Perkin Trans. I, 1982.
Haydon, D.J., et al.; An inhibitor of FtsZ with potent and selective anti-staphylococcal activity; Science 321, 2008.
Heifets, L.B., et al.; Pyrazinamide sterilizing activity in vivo against semidormant Mycobacterium tuberculosis populations; Am. Rev. Respir. Dis. 145, 1992.
Herrero et al.; Transposon Vectors Containing Non-Antibiotic Resistance Selection Markers for Cloning and Stable Chromosomal Insertion of Foreign Genes in Gram-Negative Bacteria; J Bact 172, 1990.
Hoemann, M.Z., et al.; Potent in Vitro Methicillin-Resistant Staphylococcus aureus Activity of 2-(1H-Indol-3-yl)quinoline Derivatives; Bioorg. Med. Chem. Lett. 10, 2000.
Hruby, V.; Conformational Restrictions of Biologically Active Peptides via Amino Acid Side Chain Groups (Minireview); Life Sci. 31, 1982.
Hutchinson et al.; The Development of Site-directed Mutagenesis by Michael Smith; J Biol Chem 253, 1978.
Iseman, M.D., et al.; The increasing prevalence of resistance to antituberculosis chemotherapeutic agents: implications for global tuberculosis control; Curr. Clin. Top. Infect. Dis. 12, 1992.
Johnson et al.; The efficacy of certain anti-tuberculosis drugs is affected by binding to α-1-acid glycoprotein; Biomed. Chromatogr. 20, 2006.
Karlin, et al.; Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes; Proc. Natl. Acad. Sci. USA, 87, 1990.
Karlin et al.; Applications and statistics for multiple high-scoring segments in molecular sequences; Proc. Natl. Acad. Sci. USA 90, 1993.
Kok et al.; Combining Localized PCR Mutagenesis and Natural Transformation in Direct Genetic Analysis of a Transcriptional Regulator Gene, pobR†; J Bact 179, 1997.
Kunkel, T.; Rapid and efficient site-specific mutagenesis without phenotypic selection; Proc Natl Acad Sci USA 82, 1985.
Lund et al.; Electron transfer reactions in the soluble methane monoosygenase of Methylococcus capsulatus (Bath); Eur J Biochem 147, 1985.
Malakul et al.; Metal Toxicity Reduction in Naphthalene Biodegredation by Use of Metal-Chelating Adsorbents; Appl Environ Microbiol 64, 1998.
McClay, K. et al; Biosensors for TCE Based on TCE-Induced Expression of Toluene 4-Monooxygenase from P. medocina KR1; Abstract K36, The 97th Annual Meeting of ASM, 1997.
McClay, K. et al.; Mutations of Toluene-4-Monooxygenase (T4MO) That Alter the Regiospecificity of Indole Oxidation and Lead to the Production of Novel Indigoid Pigments; Appl. Environ. Microbiol. 71, 2005.
Mermod et al.; Vector for Regulated Expression of Cloned Genes in a Wide Range of Gram-Negative Bacteria; J Bact 167, 1986.
Murrell, J.; Molecular genetics of methane oxidation; Biodegradation 5, 1994.
Myers, E., et al.; Optimal alignments in linear space; Comput. Applic. Biosci. 4, 1988.
Needleman, S. et al; A General Method Applicable to the Search for Similarities in the Amino Acid Sequence of Two Proteins; J. Mol. Biol. 48, 1970.
Pikus, J.D., et al.; Recombinant toluene 4-monoosygenase. Catalytic and Mossbauer studies of the purified diiron and Rieske components of the four protein complex; Biochemistry 35, 1996.
Pikus, J.D., et al.; Changes in the regiospecificity of aromatic hydroxylation produced by active site engineering in the diiron enzyme toluene 4-monoosygenase; Biochemistry 36, 1997.
Pikus, J.D., et al.; Role of threonine 201 in toluene 4-monoosygenase catalysis; Biochemistry 35, 2000.
Pinner, R.W., et al.; Trends in infectious disease mortality in the United States; JAMA 275, 1996.
Rosenzweig et al.; Crystal Structures of the Methane Monooxygenase Hydroxylase From Methylococcus capsulatus (Bath): Implications for Substrate Gating and Component Internations; Proteins 29, 1997.
Shields et al.; Novel Pathway of Toluene Catabolism in the Trichloroethylene-Degrading Bacterium G4; Appl Environ Microbiol 55, 1996.
Spatola et al.; Structure-Activity Relationships of Enkephalins Containing Serially Replaced Thiomethylene Amide Bond Surrogates; Life Sci. 38, 1986.
Spellberg, B., et al., 2004; Trends in antimicrobial drug development: Implications for the
McClay Kevin Rock
Steffan Robert Jon
Anderson Rebecca L
Ballard Spahr LLP
Otton Alicia L
Shaw Intellectual Properties Holding, Inc.
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