Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence
Patent
1987-03-04
1989-03-07
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
15 to 23 amino acid residues in defined sequence
C07K 708, C07K 710
Patent
active
048107778
ABSTRACT:
A new class of broad spectrum antibiotic polypeptides termed "Magainin" have been described. These peptides have a molecular weight of about 2500 or less, are highly water soluble, non-cytolyic to animal cells including red-blood cells and are amphiphilic.
REFERENCES:
patent: 4195018 (1980-03-01), Takita et al.
patent: 4409210 (1983-10-01), Kawaguchi et al.
Williams, Chemical & Engineering News, Oct. 5, 1987.
Goldsmith, Arch Dermatol, 123:1087-1088, 1987.
Zasloff Proc. Natl. Acad. Sci. USA 84:5449-5453, 1987.
Giovannini et al., Biochem. J., 243:113-120, 1987.
Csordas et al., Toxicon &;103-108, 1969.
Eisenberg, Ann Rev. Biochem. 53:595-623, 1984.
Kaiser et al., Proc. Natl. Acad. Sci. USA 80:1137-1143, 1983.
Sures et al., Proc. Natl. Acad. Sco. USA 81:380-384, 1984.
CRC Handbook of Chemotherapeutic Agents vol. I, pp. 178-185, "Peptide Antibiotics".
Kempf et al., J. Biol. Chem. 257:2469-2476, 1982.
Steiner et al., Nature 292:246-248, 1981.
Hoffmann et al., Embo, J. 2:711-714, 1983.
Andreu et al., Biochem. 149:531-535, 1985.
Merrifield et al., Biochem. 21:5020-5031, 1982.
Gibson et al., J. Biol. Chem. 261:5341-5349, 1986.
Richter et al., Peptides 6:17-21, 1985.
Phillips Delbert R.
The United States of America as represented by the Department of
Wessendorf T. D.
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