Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-01-18
1997-03-11
Lukton, David
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 514 15, 530325, 530326, 530327, A61K 3810
Patent
active
056101392
ABSTRACT:
Antimicrobial compositions which are effective against methicillin-resistant Staphylococcus aureus organisms (MRSAs) contain peptides isolated from horseshoe crabs combined with one or more .beta.-lactam antibiotics and/or chloramphenicol antibiotics. The compositions exhibit synergistic bactericidal effects against MRSAs at low concentrations, and can be used as defensive agents against opportunistic infections.
REFERENCES:
patent: 4863902 (1989-09-01), Amagase
Alpert, "Limulus Antilipopolysaccharide Factor Protects Rabbits From Meningococcal Endotoxin Shock", The J. of Infectious Diseases, 165: 494-500 (1992).
Matsuzaki, "Interactions of an Antimicrobial Peptide, Tachyplesin I, With Lipid Membranes",Biomembranes, 1070: 259-264 (1991).
Murakami, "Direct Virus Inactivation of Tachyplesin I and Its Isopeptides From Horseshoe Crab Hemocytes", Chemotherapy, 37: 327-333 (1991).
Ohta, "Mechanisms of Antibacterial Action of Tachyplesins and Polyphemusins, a Group of Antimicrobial Peptides Isolated From Horseshoe Crab Hemocytes", Antimicrobial Agents & Chemotherapy, 36: (1992).
Shigenaga, "Antimicrobial Tachyplesin Peptide Precursor", The J. of Biological Chemistry, 265: 21350-21354 (1990).
Usawattanakul, "Tachypleus Lysate Test For Endotoxin In Patients With Gram Negative Bacterial Infections", The Southeast Asian J. of Tropical Medicine And Public Health, 10: 13-17 (1979).
Zasloff, "Antibiotic Peptides As Mediators of Innate Immunity", Current Opinion in Immunology, 4: 3-7 (1992).
Blanchi, "Pharmacodynamics", Chemical Abstracts, 77:14809-14810 (1972).
JP Patent No. JP 2167230 (abstract).
JP Patent No. JP 4082840 (abstract).
JP Patent No. JP 2270897 (abstract).
JP Patent No. JP 2207098 (abstract).
JP Patent No. JP 2152987 (abstract).
JP Patent No. JP 2053799 (abstract).
Kawano, "Antimicrobial Peptide, Tachyplesin I, Isolated From Hemocytes of the Horseshoe Crab (Tachypleus tridentatus)", The J. of Biological Chemistry, 265:15365-15367 (1990).
Liang, "Studies on Limulus Amoebocyte Lysate", The J. of Biological Chemistry, 255:5586-5590 (1980).
Matsuzaki, "Interactions of an Antimicrobial Peptide, Tachyplesin I, With Lipid Membranes", Biochimica et biophysica Acta, 1070: 259-264 (1991).
Minetti, "Purification and Characterization of an Endotoxin-binding Protein with Protease Inhibitory Activity from Limulus Amebocytes", The J. of Biological Chemistry, 266: 20773-20780 (1991).
Miyata, "Antimicrobial Peptides, Isolated From Horshoe Crab Hemocytes, Tachyplesin II, and Polyphemusins I and II: Chemical Structures And Biological Activity", J. Biochem., 106:663-668 (1989).
Nakamura, "Tachyplesin, a Class of Antimicrobial Peptide from Hemocytes of the Horseshoe Crab (Tachypleus tridentatus)", The J. of Biological Chemistry, 263:16709-16713 (1988).
Shieh, "Synthesis and Properties of Tachyplesin I, a Lipopolysaccharide-Binding Peptide, From Tachypleus tridentatus", Febs Letters, 252: Nos. 1, 2, pp. 121-124 (Jul. 1989).
Nester et al., Microbiology, Holt Rinehart and Winston, Inc., New York, 1973, p. 190.
The Merck Index, 9th ed., Martha Windholz, Editor, Merck and Co., Inc. Rahway, N.J. 1976, p. 245 Entry No. 1911.
The Merck Index, 9th ed., Merck & Co. Inc. Rahway, N.J. 1976, p. 261, entry No. 2040.
Kato Nobuo
Ohta Michio
Lukton David
Seikagaku Corporation
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