Antimicrobial combination therapy

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 3,10-dihydroxy-2-naphthacene carboxamide or derivative doai

Reexamination Certificate

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Details

C514S154000, C514S492000, C514S579000, C514S740000, C552S203000, C424S649000

Reexamination Certificate

active

07943600

ABSTRACT:
This invention provides methods and pharmaceutical compositions for treating a subject having a condition associated with an antibiotic resistant bacterial infection. The invention includes administering to a subject a therapeutically effective combination of an antibiotic and a toxic compound (e.g., a nucleic acid damaging agent, an alkylating agent, or a heavy metal containing compound).

REFERENCES:
patent: 4386070 (1983-05-01), De Vincentiis
patent: 4419351 (1983-12-01), Rosenberg et al.
patent: 5064821 (1991-11-01), Levy
patent: 1 364 652 (2003-11-01), None
patent: WO 02/24201 (2002-03-01), None
B. Rosenburg, L. Van Camp, T. Krigas, Inhibition of cell division inEscherichia coliby electrolysis products from a platinum electrode, Nature, vol. 205(1965), pp. 698-699.
Rybak et al. 1996, Combination Antimicrobial Therapy for bacterial infections. Drugs. vol. 52(3), pp. 390-405.
Jacobs et al., Synergism between gentamicin and mitomycin C in staphylococcal infections in mice. Chemotherapy. 1985;31(5):389-94.
Rudy et al., [Effects of disodium salt of ethylenediaminetetraacetic acid (Na2EDTA) and tetracyclines on drug resistant bacteria. Studies in vitro] Med Dosw Mikrobiol. 1991;43(3-4):127-34. Polish. Abstract Only.

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